T71127
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Ipconazole is a member of the class of cyclopentanols carrying 1,2,4-triazol-1-ylmethyl, 4-chlorobenzyl and isopropyl substituents at positions 1, 2 and 5 respectively. Used to control a range of seed diseases in rice, vegetables and other, mainly non-food, crops. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of cyclopentanols, a member of monochlorobenzenes, a member of triazoles, a tertiary alcohol, a conazole fungicide and a triazole fungicide. |
T64105
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Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物,对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用,表现出抗真菌效果。 |
T9802
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Penconazole 是一种典型的三唑类杀菌剂 (fungicide),主要用于苹果、葡萄、蔬菜等的白粉病防治。Penconazole 抑制真菌甾醇生物合成。Penconazole 降低大鼠大脑和小脑AChE 活性。 |
T7866
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Others
Antifungal
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Difenoconazole 是一种广谱三唑类杀菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。 |
T82108
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ICMT-IN-35(即compound 10n),作为FTPA-triazole类ICMT抑制剂(IC50=0.8 μM),能被哺乳动物细胞吸收并阻断K-Ras膜定位,进而诱导K-Ras错定位。ICMT-IN-35对ICMT+/+MEF细胞表现出选择性细胞毒性,对转移性胰腺癌细胞系展示低微摩尔级别活性(IC50=0.8 μM)。 |
T63314
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Antifungal agent 31 是口服具有活力的、拥有吡咯三嗪酮支架的三唑类抗真菌剂,对念珠菌和丝状真菌表现出一定的抗真菌作用。Antifungal agent 31 能够明显减少两种致死性全身感染小鼠模型的死亡率和肾脏真菌负担。 |
T60338
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Antibacterial agent 117是一种三唑衍生物,可作为抗菌剂。Antibacterial agent 117 具有抗 R. prowazekiiMetAP1 (RpMetAP1)活性,其 IC50值为 15 μM。Antibacterial agent 117 也可抑制立克次体生长,可用于感染的研究。 |
T35693
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N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1
1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017) |
T35450
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α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response. |
T17731
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Others
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CL2A-SN-38 是一种药物-接头偶联物,由一种有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成,用于制造抗体药物偶联物。它对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 |