目录号 | 产品详情 | 靶点 | |
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T2855 | PDE PPAR Autophagy | ||
Icariin (Ieariline) 是一种黄酮醇苷,可抑制PDE5和PDE4活性,IC50分别为 432 nM 和 73.50 μM。它也是PPARα激活剂。 | |||
T15381 | PDE | ||
Gisadenafil (UK-369003) 是一种特异性磷酸二酯酶 5 (PDE5) 抑制剂,IC50 为 3.6 nM,可防止 cGMP 降解。 | |||
T13189 | PDE | ||
TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂,IC50 为 0.8 nM。 | |||
T5956 | GSK-3 PDE | ||
VP3.15 dihydrobromide 是一种口服具有活力的、高效的、CNS 可渗透的PDE7-GSK3双重抑制剂,对 PDE7 和 GSK3 作用的IC50值分别为 1.59 μM 和 0.88 μM。它具有神经保护和神经修复作用,可用于研究多发性硬化症 (MS) 潜在的抗炎和促髓鞘再生联合。 | |||
T9816 | PDE | ||
Arofylline (LAS 31025) 是一种 PDE4 抑制剂,可用于哮喘的研究。 | |||
T12103 | PDE | ||
MR-L2 是可逆的、非竞争性的长型异构体磷酸二酯酶 -4激活剂,可以激活代表性的 PDE4 长型异构体 (PDE4A4、PDE4B1、PDE4C3、PDE4D5)。它可抑制 PGE2- 诱导的 MDCK 细胞囊肿形成,其EC50=1.2 µM。 | |||
T2137 | PDE | ||
Ibudilast (MN-166) 是一种环腺苷酸磷酸二酯酶 (PDE) 抑制剂,具有抗血小板聚集作用。它能够抑制气管平滑肌收缩性,可用于研究哮喘。它可对抗活化小胶质细胞的神经毒性,可能是一种有效的神经保护和抗痴呆药物。 | |||
T1265 | TNF PDE | ||
Amrinone (Inocor) 是一种正性肌力血管扩张剂,是一种具有口服活性的,非糖苷和非儿茶酚胺的强心剂,也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂,能够防止环磷酸腺苷分解,从而增加环磷酸腺苷水平。 | |||
T3783 | OAT transporter PDE | ||
Fraxin (Fraxoside) 是一种白蜡树内酯的糖苷,可从Acer tegmentosum,F. ornus 和A. hippocastanum 等分离得到,具有抗氧化、抗炎和抗转移活性。它能够抑制环腺苷酸磷酸二酯酶,具有抗氧化作用。 | |||
T8462 | PDE | ||
Enoximone 是一种选择性的,具有口服活性的磷酸二酯酶 III 抑制剂,也是正性肌力血管舒张剂。它通过抑制 cGMP 抑制的 PDE 来诱导血管舒张并增加细胞内 cAMP 水平。它还表现出 PDE4抑制作用,对心肌 PDE4A 的 IC50为 21.1 μM。它用于充血性心力衰竭的研究,并具有支气管扩张,抗哮喘和抗炎作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04006 | ENPP3 Protein, Rhesus, Recombinant (His) | Rhesus | Baculovirus Insect Cells | ||
ENPP3 Protein, Rhesus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 97.2 kDa and the accession number is XP_001103528.1.
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TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1.
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TMPY-02585 | Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood.
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TMPH-00571 | ACP phosphodiesterase Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
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TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ENPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is AAH34961.1.
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TMPY-01922 | PDE9A Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
PDE9A Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.5 kDa and the accession number is O76083-2.
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TMPY-01921 | PDE9A Protein, Human, Recombinant (His) | Human | E. coli | ||
PDE9A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 40 kDa and the accession number is O76083-2.
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TMPH-02425 | ENPP3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
ENPP3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 98.7 kDa and the accession number is A0A2K5TKP4.
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TMPY-01819 | PDE1B Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It binds two divalent metal cations per subunit. Site one of PDE1B may preferentially bind zinc ions, while site two of PDE1B has a preference for magnesium and/or manganese ions. PDE1B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. It has a preference for cGMP as a substrate.
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TMPY-02081 | PDE2A Protein, Human, Recombinant (aa 215-900, His) | Human | Baculovirus Insect Cells | ||
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. PDE2A contains two GAF domains. PDE2A is expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. PDE2A is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. PDE2A is involved in the regulation of blood pressure and fluid homeostasis by the atrial natriuretic peptide (ANP), making PDE2-type enzymes important targets for drug discovery.
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TMPY-02977 | PDE1C Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory. PDE1C has a high affinity for both cAMP and cGMP. It is expressed in several tissues, including brain and heart. As a cyclic nucleotide phosphodiesterase, PDE1C has a dual-specificity for the second messengers cAMP and cGMP.
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TMPY-03278 | SMPDL3A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SMPDL3A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.3 kDa and the accession number is Q92484.
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TMPY-02253 | ENPP7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ENPP7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q3TIW9.
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TMPY-02880 | ENPP5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ENPP5 is a member of the nucleotide pyrophosphatase/phosphodiesterase family (NPP). It is a family comprised of dimeric enzymes that catalyze the hydrolysis of phosphate diester bonds. There are seven isoforms in NPP family, some of which prefer nucleotide substrates, some of which prefer phospholipid substrates, and others of which prefer substrates that have not yet been determined. NPP also belongs to the alkaline phosphatase (AP) superfamily of enzymes and they are located in the cell membrane and hydrolyze extracellular phosphate diesters to affect a wide variety of biological processes. ENPP5 belongs to a group of nucleotidemetabolizing ectoenzymes, which regulate the availability of extracellular nucleotides. ENPP5 may play a role in neuronal cell communication. However, it lacks nucleotide pyrophosphatase and lysopholipase D activity. It may also be involved in neuronal cell communication. The amino acid sequence of human ENPP5 is 100%, 88%, and 82% identical to that of chimpanzee, dog and mouse/rat. ENPP5 functions in phospholipid metabolism.
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TMPY-04512 | SMPDL3A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
SMPDL3A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.1 kDa and the accession number is P70158.
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TMPY-01070 | ENPP7 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ENPP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49 kDa and the accession number is Q6UWV6.
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TMPY-02055 | ENPP2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ENPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is Q9R1E6-1.
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TMPY-06858 | ENPP3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ENPP3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96.44 kDa and the accession number is O14638.
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TMPH-01024 | Calbindin Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937.
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TMPK-00854 | ENPP1 Protein, Human, Recombinant (C-His) | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413.
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TMPH-00270 | GNAT2 Protein, Bovine, Recombinant (His) | Bovine | E. coli | ||
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. GNAT2 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P04696.
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TMPK-00781 | ENPP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 95.99 kDa and the accession number is P06802-1.
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TMPK-00853 | ENPP1 Protein, Human, Recombinant (N-His) | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413.
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TMPK-00852 | ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 98.29 kDa and the accession number is P22413.
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TMPK-00712 | ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi) | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 17.21 kDa and the accession number is O14638.
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TMPK-00573 | ENPP3 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.19 kDa and the accession number is A0A8I3N0F5.
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TMPH-02575 | PDE5A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. PDE5A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.1 kDa and the accession number is Q8CG03.
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TMPK-00715 | ENPP3 Protein, Human, Recombinant (aa 558-875, His) | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 558-875, His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 39.06 kDa and the accession number is O14638.
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TMPK-00713 | ENPP3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 99.97 kDa and the accession number is O14638.
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TMPK-00714 | ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi), Biotinylated | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 17.21 kDa and the accession number is O14638.
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TMPK-00711 | ENPP3 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 99.97 kDa and the accession number is O14638.
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