目录号 | 产品详情 | 靶点 | |
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T7306 | Opioid Receptor | ||
Valorphin (Valorphin TFAsalt) 是内源性血红蛋白 β 链第 33-39 位氨基酸残基,具有阿片类镇痛活性,与大鼠 mu-阿片受体结合,IC50 为 14 nM。它有抗肿瘤活性,也可用于缓解疼痛的研究。 | |||
TP1559L | Calcium Channel | ||
Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂,已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用,因此通过有效的镇痛作用减少突触传递。 | |||
T7567 | Opioid Receptor | ||
Adrenorphin (Metorphamide) 是一种 μ 阿片受体激动剂,Ki 值为 12 nM。 | |||
T6414 | Others | ||
Bisacodyl (Fenilaxan) 是刺激性缓泻剂,可直接作用于结肠以产生排便。它能够直接激活结肠巨噬细胞来增加 PGE2的分泌。PGE2充当旁分泌因子并减少结肠中 AQP3 的表达,抑制水从腔向血管一侧的转移,进而产生通便作用。 | |||
TP1793 | Opioid Receptor | ||
Nociceptin (1-13), amide 是一种 ORL1 (OP4) 受体激动剂,与大鼠前脑膜结合的 Ki 为 0.75 nM,对小鼠输精管的 pEC50 为 7.9。 | |||
T16399 | P2X Receptor GlyT 5-HT Receptor | ||
Opiranserin 是一种非阿片类和非 NSAID 镇痛候选药物,是 2 型甘氨酸转运蛋白 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂,IC50分别为 0.86 和 1.3 μM。它可用于术后疼痛的研究,对 rP2X3 有拮抗作用,IC50为0.87 μM。 | |||
T7173L | Opioid Receptor Endogenous Metabolite | ||
[Leu5]-Enkephalin acetate(58822-25-6 free base) 是一种参与伤害感受的内源性神经肽,是 δ-opioid 和 μ-opioid 受体的激动剂(Kis 分别为 4.0 和 3.4 nM) | |||
T7567L | Opioid Receptor | ||
Adrenorphin 3TFA(88377-68-8(free base)) (Metorphamide) 是 μ-opioid 受体 (Ki :12 nM) 的激动剂。 | |||
T11909 | Opioid Receptor | ||
LY2444296 (FP3FBZ) 是 kappa opioid receptor (Ki = 1 nM) 的具有口服活性的和选择性拮抗剂。 | |||
T0963 | Opioid Receptor | ||
Naltrexone hydrochloride (Naltrexone HCl) 是一种合成的 opiate 拮抗剂,用于预防 opiate 成瘾和酗酒的复发。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04733 | OPCML Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
OPCML Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is P32736-1.
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TMPY-00893 | OPCML Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
OPCML Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34 kDa and the accession number is A8K0Y0.
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TMPY-03818 | OPCML Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
OPCML Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is Q6DFY2.
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TMPJ-00737 | PDYN Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkephalins, which is a type of Proenkephalin-B, compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
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TMPH-02020 | RGS17 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. RGS17 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 51.4 kDa and the accession number is Q9UGC6.
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TMPJ-00513 | LTF Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Lactotransferrin is a member of the transferrin family that transfer iron to the cells and control the level of free iron in the blood and external secretions. Lactotransferrin is a secreted protein and contains two transferrin-like domains. Lactotransferrin can be cleaved into the following four chains: Kaliocin-1, Lactoferroxin-A, Lactoferroxin-B, and Lactoferroxin-C. Lactoferroxin A, Lactoferroxin B, and Lactoferroxin C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while Lactoferroxin B and Lactoferroxin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. LTF has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses.
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TMPY-04121 | NAGA Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NAGA (Alpha-N-Acetylgalactosaminidase) is a Protein Coding gene. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. It belongs to the glycosyl hydrolase 27 family. The antinociceptive effect of NAGA may involve the participation of endogenous opioid peptides and endogenous catecholamines. Normal alpha-NAGA is synthesized as a 52 kDa precursor which matures to a 49 kDa species through phosphorylation and carbohydrate trimming. Mutations in gene encoding alpha-NAGA cause a wide range of diseases, characterized by mild to severe clinical features. NAGA is widely expressed in the placenta, appendix, and other tissues. Diseases associated with NAGA include Kanzaki Disease and Schindler Disease, Type I.
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