目录号 | 产品详情 | 靶点 | |
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T11070L | Others | ||
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). | |||
T2806L | |||
Lappaconitine HCl is a centrally acting non-opioid analgesic and class-I antiarrhythmic. It acts by binding to the site-2 receptor and irreversibly blocking hH1 sodium channels. | |||
T71343 | |||
GSK1997132B is a potent, metabolically stable and centrally penetrant PPARγ partial agonist. | |||
T21372 | |||
Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses. | |||
T22435 | Others | ||
Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. | |||
T14334 | GlyT | ||
ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1]. | |||
T15165 | Opioid Receptor | ||
DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally acting agents. | |||
T66676 | |||
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. | |||
T79431 | Opioid Receptor | ||
Muopioid receptorantagonist 7 (compound 24) 是一种有效的CNS渗透性μOR (μ-阿片受体)拮抗剂,具有29 ± 3.0 nM的IC50。该化合物可用于研究疼痛和阿片类药物使用障碍。 | |||
T40744 | |||
Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator effect. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells | ||
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / JNKK1 has been shown to activate MAPK8 / JNK1, MAPK9 / JNK2, and MAPK14 / p38, but not MAPK1 / ERK2 or MAPK3 / ERK1. MAP2K4 / JNKK1 is phosphorylated, and thus activated by MAP3K1 / MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.
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TMPY-01778 | EphA4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
EphA4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is Q03137-1.
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TMPY-04082 | EphA3 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
EphA3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.7 kDa and the accession number is Q8BRB1.
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TMPY-04447 | EphA3 Protein, Mouse, Recombinant (aa 569-984, His & GST) | Mouse | Baculovirus Insect Cells | ||
EphA3 Protein, Mouse, Recombinant (aa 569-984, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.3 kDa and the accession number is EDK98238.1.
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TMPY-04448 | EphA3 Protein, Mouse, Recombinant (aa 569-984) | Mouse | Baculovirus Insect Cells | ||
EphA3 Protein, Mouse, Recombinant (aa 569-984) is expressed in Baculovirus insect cells. The predicted molecular weight is 46.6 kDa and the accession number is EDK98238.1.
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TMPY-02493 | EphA3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
EphA3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.2 kDa and the accession number is Q8BRB1.
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TMPY-01779 | EphA4 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
EphA4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.3 kDa and the accession number is Q03137-1.
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