目录号 | 产品详情 | 靶点 | |
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T0214 | Ferroptosis PPAR | ||
Pioglitazone (U 72107) 是一种胰岛素增敏剂和噻唑烷二酮,适用于治疗 2 型糖尿病。它是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域,作用于人和鼠 PPARγ的EC50分别为 0.93 和 0.99 μM。 | |||
T5701 | RAAS Calcium Channel NF-κB PPAR | ||
Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物,是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂,用于炎症和心血管疾病的相关研究。 | |||
T5S1550 | PPAR | ||
Cinnamyl alcohol (Styryl Carbinol) 是从板栗花中分离得到的一种活性成分,抑制增加的 PPARγ表达,具有抗肥胖作用。 | |||
T1402 | MMP COX PPAR | ||
Fenofibric acid (FNF acid) 是 fenofibrate 的活性代谢物,是PPAR 激动剂,对 PPARα、PPARγ 和 PPARδ 的EC50值分别为 22.4、1.47 和 1.06 µM。它抑制COX-2的活性,IC50值为 48 nM。 | |||
T16074 | PPAR | ||
Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂,可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性,IC50为140 μM,具有抗肥胖和抗糖尿病作用。 | |||
T7821 | PPAR | ||
DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂,IC50值为 27 nM。 | |||
T63561 | |||
PPARγ agonist 5 是选择性的、有效的 PPARγ 激动剂,对癌症疾病表现出研究潜力。 | |||
T12296 | Endogenous Metabolite PPAR | ||
Oleoylethanolamide (N-Oleoylethanolamide) 是一种PPAR-α 的高亲和力内源性激动剂,可用于肥胖和动脉硬化的相关研究。 | |||
T1415 | P450 Adrenergic Receptor PPAR | ||
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。 | |||
T8638 | Others | ||
NPC 15199 (FMOC-L-Leucine) 是选择性的PPARγ调节剂。它对 PPARγ 的激活效果比罗格列酮低,但二者最大效应相似。它能够改善正常、饮食诱导的葡萄糖不耐受和糖尿病 db/db 小鼠的胰岛素敏感性,一定程度上能够诱导脂肪生成。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
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TMPY-06837 | PPAR alpha/PPARA Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204.
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TMPY-06830 | PPAR alpha/PPARA Protein, Human, Recombinant (His) | Human | E. coli | ||
PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869.
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TMPH-02827 | PPAR gamma Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
PPAR gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is P37238.
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TMPH-03711 | PPAR gamma Protein, Xenopus laevis, Recombinant (His) | Xenopus laevis | E. coli | ||
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
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TMPH-02855 | PML Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV).
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