目录号 | 产品详情 | 靶点 | |
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T6893 | Apoptosis Leukotriene Receptor COX PPAR FLAP | ||
MK-886 (L 663536)是一种细胞可渗透的,具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。它也是一种非竞争性PPARα拮抗剂,可以诱导细胞凋亡。 | |||
TN1182 | Leukotriene Receptor NF-κB Lipoxygenase | ||
11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸,具有抗炎活性和剂量依赖性心脏保护作用,主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。 | |||
T61910 | |||
COX-2/5-LOX-IN-2 是苯并噻吩-2-基吡唑羧酸衍生物。COX-2/5-LOX-IN-2 (5b) 对COX-2和5-LOX 均有抑制作用。COX-2/5-LOX-IN-2 抑制 COX-1、COX-2 和 5-LOX 的IC50s 分别为 5.40、0.01 和 1.78 μM。COX-2/5-LOX-IN-2 显示出超过塞来昔布和吲哚美辛的镇痛和抗炎活性。 | |||
T79361 | Lipoxygenase | ||
COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂,具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子(IL-6, ROS和NO),表明其具备显著的抗炎活性。 | |||
T27026 | Lipoxygenase | ||
CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。 | |||
T22502 | Lipoxygenase | ||
2-TEDC 是一种有效的脂氧合酶(LOX)抑制剂,对 5-LOX、12-LOX 和 15-LOX 具有抑制作用,IC50 值分别为 0.09 μM、0.013 μM 和 0.5 μM。2-TEDC 可用于研究动脉粥样硬化。 | |||
T60438L | Lipoxygenase | ||
PXS-6302 hydrochloride 是一种有效的不可逆赖氨酸氧化酶 (LOX) 抑制剂,对 Bovine LOX、rh LOXL1、 rh LOXL2、rh LOXL3 和 rh LOXL4 具有抑制作用, IC50 分别为 3.7 μM ,3.4 μM ,0.4 μM ,1.5 μM,0.3 μM。PXS-6302 hydrochloride 易透过皮肤,能够减少胶原蛋白堆积,显著改善疤痕外观。 | |||
T34624 | Lipoxygenase | ||
Setileuton (MK0633) 是一种特异性 5-LOX 抑制剂,可用于哮喘和动脉粥样硬化的研究。 | |||
T21838 | Lipoxygenase | ||
1-Naphthyl 3,5-dinitrobenzoate (JMC-4) 是 5-LOX 的抑制剂,可用于炎症治疗的研究。 | |||
T9878 | Lipoxygenase LTR | ||
Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPK-01168 | LOX-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
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TMPY-02490 | LOX-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
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TMPY-03462 | 15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 103.7 kDa and the accession number is AAH35217.1.
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TMPY-03553 | 15 Lipoxygenase 2 Protein, Human, Recombinant | Human | Baculovirus Insect Cells | ||
15 Lipoxygenase 2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 76 kDa and the accession number is AAH35217.1.
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TMPY-03351 | LOX-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
LOX-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.9 kDa and the accession number is G7PJT2.
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TMPH-02863 | LOX Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells | ||
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
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TMPH-01968 | LOX Protein, Human, Recombinant (His & MBP) | Human | Baculovirus Insect Cells | ||
LOX Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus.
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TMPH-03359 | LOX Protein, Rat, Recombinant (His) | Rat | E. coli | ||
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.0 kDa and the accession number is P16636.
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TMPY-03371 | LOX-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
LOX-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.9 kDa and the accession number is O70156.
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TMPY-04066 | LOX-1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
LOX-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is O70156.
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TMPH-01969 | LOX Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 49.0 kDa and the accession number is P28300.
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TMPH-00955 | ALOX12 Protein, Human, Recombinant (His) | Human | E. coli | ||
ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPY-00203 | LOXL2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.
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TMPH-00866 | ADAMTS14 Protein, Human, Recombinant (His) | Human | E. coli | ||
Has aminoprocollagen type I processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form. ADAMTS14 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.2 kDa and the accession number is Q8WXS8.
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TMPH-01552 | IRF1 Protein, Human, Recombinant (GST & His) | Human | Baculovirus Insect Cells | ||
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
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