T73857
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Mesembrine ((+)-Mesembrine) 一种主要的生物碱,具有芳基八氢吲哚骨架。Mesembrine 是一种5-HT 转运蛋白抑制剂,Ki 为 1.4 nM。Mesembrine 还抑制磷酸二酯酶 4B (PDE4B),IC50为 7.8 μM。 |
T25025
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ALB-109564 dihydrochloride 是长春碱生物碱的半合成衍生物,是一种微管蛋白抑制剂和抗肿瘤药物。它与微管蛋白单体结合并抑制微管的形成,导致有丝分裂纺锤体组装的破坏和肿瘤细胞停滞在细胞周期的G2/M 期。 |
TN2203
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Senecionine n-oxide 是千里光寻常型根部培养物中吡咯烷核生物碱生物合成的主要产物,Senecionine N-oxide (Senecionine oxide) 具有抗肿瘤活性,但可诱导肝窦阻塞综合征。Senecionine n-oxide可作为 N-氧化物螯合示踪剂。 |
T36101
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Psychotridine is an alkaloid that has been found inP. forsterianaand has diverse biological activities.1,2,3It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50values of 1.4, 1.4, and 3.9 μM, respectively.1Psychotridine (2.5 or 5 μM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.3
1.Beretz, A., Roth-Georger, A., Corre, G., et al.Polyindolinic alkaloids from Psychotria forsteriana. Potent inhibitors of the aggregation of human plateletsPlanta Med.51(4)300-303(1985) 2.Roth, A., Kuballa, B., Bounthanh, C., et al.Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana (Rubiaceae) (1)Planta Med.6450-453(1986) 3.Amador, T.A., Verotta, L., Nunes, D.S., et al.Involvement of NMDA receptors in the analgesic properties of psychotridinePhytomedicine8(3)202-206(2001) |
T75439
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Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱,展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用,证明了其抗菌活性。 |
TN2344
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Apoptosis
Others
Antibiotic
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Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱,是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性,可诱导细胞凋亡和细胞周期停滞在 G2/M 期。 |
T35909
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Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 μM for both).1 Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.2 It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 μg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 μg/ml).
|1. Naveen, B., Ommi, N.B., Mudiraj, A., et al. Total synthesis of penicinoline E, marinamide, methyl marinamide and their antimalarial activity. ChemistrySelect 2(11), 3256-3261 (2017).|2. Shao, C.-L., Wang, C.-Y., Gu, Y.-C., et al. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett. 20(11), 3284-3286 (2010). |
T79639
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Ferroptosis
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Lepadin H 是一种具有显著细胞毒性的海洋生物碱,能够诱导铁死亡。它通过增加 p53 表达、提升 ROS 生成和脂质过氧化来展开作用,同时抑制 SLC7A11 和 GPX4,上调 ACSL4。Lepadin H 主要通过 p53-SLC7A11-GPX4 路径实现其诱导铁死亡的功能。 |
T73813
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Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。 |
T75333
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Quinine hemisulfate hydrate,一种从金鸡纳树皮提取的生物碱,具有抗疟疾效果。作为钾离子通道 (potassium channel) 抑制剂,它能够抑制由电压脉冲触发的MT mSlo3 (KCa5.1) 通道在+100 mV下的电流活动,其IC50值达169 μM。 |