目录号 | 产品详情 | 靶点 | |
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T78750 | NF-κB | ||
NF-κB-IN-10(化合物E1)是一种调节Nrf2/NF-κB信号通路的NF-κB抑制剂,能减少氧化应激与炎症,有助于心力衰竭治疗。它可抑制RAW264.7细胞LPS诱导的NO生成,并降低iNOS和COX-2的表达,适用于心血管疾病研究。 | |||
T61181 | |||
Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-κB, further enhancing its apoptotic effects. [1] | |||
T68919 | |||
Nabumetone alcohol is the alcohol form of nabumetone, a non-steroidal anti-inflammatory drug (NSAID) that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid, which inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). | |||
TMIH-0281 | |||
Indobufen-d5 是 Indobufen 的氘代化合物。Indobufen 的 CAS 号为 63610-08-2。Indobufen 是一种血小板聚集抑制剂,是下调单核细胞中的组织因子,可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。 | |||
T70431 | |||
TX-1123是一种针对Src、eEF2-K、PKA和EGFR-K/PKC的有效蛋白酪氨酸激酶(PTK)抑制剂,同时也是一种环氧合酶(COX)抑制剂,对COX2和COX1的IC50值分别为1.16μM和15.7μM。它具有低线粒体毒性,可用于癌症研究。 | |||
TMA0291 | GSK-3 p38 MAPK ROS Akt COX PI3K DNA/RNA Synthesis Prostaglandin Receptor JNK | ||
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. | |||
T37374 | |||
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management. | |||
T37633 | |||
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM). | |||
T37774 | |||
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM). | |||
T36070 | |||
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01736 | COX-2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPH-01179 | COX4I1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-01180 | COX5A Protein, Human, Recombinant (GST) | Human | E. coli | ||
COX5A Protein, Human, Recombinant (GST) is expressed in E. coli.
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TMPY-03511 | COX5B Protein, Human, Recombinant (His) | Human | E. coli | ||
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.
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TMPY-03752 | COX4NB Protein, Human, Recombinant (His) | Human | E. coli | ||
COX4NB Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O43402.
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TMPH-02617 | COX5A Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
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TMPY-04908 | Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) | CV | Baculovirus Insect Cells | ||
Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 59.5 kDa and the accession number is AAA50478.1.
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TMPY-04807 | Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) | CV | Baculovirus Insect Cells | ||
Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 32.6 kDa and the accession number is AAA50478.1.
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TMPH-03639 | COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) | Trachypithecus cristatus | HEK293 Cells | ||
N/A. COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.9 kDa and the accession number is Q9N234.
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TMPJ-00704 | SCO1 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.
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TMPY-03658 | ETHE1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic encephalopathy is an autosomal recessive, invariably fatal disorder characterized by early-onset encephalopathy, microangiopathy, chronic diarrhea, defective cytochrome c oxidase (COX) in muscle and brain, high concentrations of C4 and C5 acylcarnitines in blood and high excretion of ethylmalonic acid in urine.
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