目录号 | 产品详情 | 靶点 | |
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T4S1658 | NF-κB Tyrosinase | ||
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂,分离于Paeonia suffruticosa 的根,对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂,它通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。 | |||
T61817 | |||
Tyrosinase-IN-6 (Compound 4B) demonstrated the highest efficacy as a tyrosinase inhibitor (ic50 = 3.80 μM), in addition to exhibiting favorable antioxidant activity. | |||
T72703 | |||
Tyrosinase-IN-11 是一种有效的酪氨酸酶 (tyrosinase) 抑制剂,对 L-酪氨酸酶和 L-多巴的 IC50值分别为 50 nM 和 64 nM。Tyrosinase-IN-11 具有显着的抗氧化活性和低细胞毒性。Tyrosinase-IN-11 具有用于皮肤色素沉着过度研究的潜力。 | |||
T61425 | |||
Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1]. | |||
T79401 | Tyrosinase | ||
Tyrosinase-IN-13 (compound 3c)为Flurbiprofen的衍生物,具有非竞争性酪氨酸酶抑制活性(IC50=68 μM;Ki=36.3 μM),并对肝细胞癌(HepG2)、结直肠癌(HT-29)及黑色素瘤(B16F10)细胞表现出细胞毒性。 | |||
T60484 | |||
Tyrosinase-IN-4 (compound 34) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种有前途的靶点,酪氨酸酶抑制剂可用作皮肤美白剂和食品防腐剂。 Tyrosinase-IN-4 在食品、化妆品、农业和医药等领域具有应用潜力[1]。 | |||
T72787 | |||
Tyrosinase-IN-8, 作为一种酪氨酸酶抑制剂, 具有1.57 µM的IC50值,其特点是低细胞毒性地抑制细胞生长。 | |||
T79406 | Tyrosinase | ||
Tyrosinase-IN-14 (compound 7m) 是一种针对酪氨酸酶的抑制剂, 它通过改变酪氨酸酶的二级结构来降低其催化活性。此化合物的细胞毒性较低, 并且在水果抗褐变方面显示出活性。特别是,Tyrosinase-IN-14 在抑制香蕉储藏期间的褐变方面表现出了有效性。 | |||
T5980 | Tyrosinase Endogenous Metabolite | ||
2-Ketoglutaric acid 是 Krebs 循环的中间体,可以产生 ATP 或 GTP 。2-Ketoglutaric acid 还充当氮同化反应的主要碳骨架。2-Ketoglutaric acid 是酪氨酸酶(tyrosinase)的可逆抑制剂 (IC50=15 mM)。 | |||
T4587 | Tyrosinase | ||
Mirificin (BCP10902) 是一种葛根中的异黄酮。它能够抑制酪氨酸酶(Tyrosinase),IC50=12.66 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02269 | Tyrosinase/TYR Protein, Human, Recombinant (His) | Human | Yeast | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02270 | Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02751 | DCT Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
DCT Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-01608 | DCT Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
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