目录号 | 产品详情 | 靶点 | |
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T60535 | |||
PPARα/γ agonist 1 是一种有效的双重 PPARα/γ部分激动剂,是用于研究血脂异常和糖尿病的有前途的化合物。PPARα/γ agonist 1 对 PPARα 和 PPARγ 的EC50值分别为 28 nM 和 69 nM。 | |||
T62205 | |||
Pparδ agonist 7 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族,在体内代谢稳态、炎症、细胞生长和分化的调节中发挥着关键作用。Pparδ agonist 7 对非酒精性脂肪肝 (NAFLD) 表现出研究潜力。 | |||
T2260 | PPAR | ||
GW9662 (TIMTEC-BB SBB006523) 是一种特异性 PPARγ 拮抗剂,IC50值为3.3 nM,在细胞中对 PPARγ 的功能选择性是 PPARα/δ 的 10 到 1000 倍。 | |||
T23389 | PPAR | ||
SR1664 是一种PPARγ拮抗剂,与结合PPARγ,可有效抑制 Cdk5 介导的PPARγ磷酸化,IC50为80 nM,Ki 为 28.67 nM。 | |||
T67936 | PPAR | ||
BAY-0069 是一种 PPARγ 反向激活剂,具有有效性和选择性,对人 PPARγ 和鼠 PPARγ 具有抑制作用, IC50 分别为 6.3 nM 和 24 nM。BAY-0069 可用于研究癌症。 | |||
T3170 | Apoptosis Ferroptosis PPAR Autophagy | ||
Troglitazone (Romglizone) 是一种 PPARγ 激动剂,具有抗炎和抗肿瘤活性。 | |||
T16074 | PPAR | ||
Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂,可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性,IC50为140 μM,具有抗肥胖和抗糖尿病作用。 | |||
T6689 | PPAR | ||
T0070907 是一种有效且特异性的 PPARγ 抑制剂,Ki 值为1 nM,其选择性比 PPARα 和 PPARδ 高 800 倍以上。 | |||
T38715 | PPAR | ||
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide. | |||
T0214L | Ferroptosis PPAR | ||
Pioglitazone hydrochloride (AD 4833) 是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ,EC50分别为 0.93 和 0.99 μM。它是一种口服活性噻唑烷二酮的盐酸盐,具有抗糖尿病特性和潜在的抗肿瘤活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
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TMPH-02827 | PPAR gamma Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
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TMPY-06830 | PPAR alpha/PPARA Protein, Human, Recombinant (His) | Human | E. coli | ||
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPH-03711 | PPAR gamma Protein, Xenopus laevis, Recombinant (His) | Xenopus laevis | E. coli | ||
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
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TMPY-06837 | PPAR alpha/PPARA Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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