目录号 | 产品详情 | 靶点 | |
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T60726 | |||
OYYF-175 是一种抗菌抗叶酸剂。OYYF-175具有有效的广谱抗菌活性,尤其是针对多重耐药革兰氏阴性菌株。OYYF-175是一种二氢叶酸还原酶 (DHFR) 抑制剂,其对大肠杆菌 DHFR 的 IC50为 2.36 nM。 | |||
T25981 | |||
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T25980 | |||
Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T70304 | |||
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia. | |||
T78238 | DHFR Antifungal | ||
4′-DTMP (4-Demethyltrimethoprim) 是一种有效的 DHFR 抑制剂,具有抗菌活性,诱导与酶的额外局部相互作用,对大肠杆菌具有抑制作用。 | |||
T60938 | |||
EGFR/HER2-IN-8 (compound 34) 是EGFR/HER2和DHFR 的抑制剂,其对 EGFR,HER2 和 DHFR 的IC50值分别为 0.45,0.244 和 5.669 μM。EGFR/HER2-IN-8 可用于癌症研究,它对多种癌细胞系表现出抗癌活性,具有高安全性和选择性指数。 | |||
T60699 | |||
Aditoprime (Aditoprim) 是细菌二氢叶酸还原酶(DHFR)的选择性抑制剂。Aditoprime 抑制二氢叶酸向四氢叶酸的转化。Aditoprime 显示出良好的抗菌活性,具有广谱抗菌性,并且显示出良好的药代动力学。Aditoprime 抑制干酪乳杆菌和大肠杆菌 DHFR 的 IC50分别为520和47 nM。 | |||
T68684 | |||
Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule. | |||
T61732 | |||
EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This compound displays notable anticancer properties in various cancer cell lines, while demonstrating a favorable safety profile and selectivity indices. Consequently, EGFR/HER2-IN-6 holds promise as a valuable tool in cancer research [1]. | |||
T0189 | DHFR DNA/RNA Synthesis Antifolate Autophagy | ||
Pemetrexed (LY-231514 Disodium Hydrate) acid 是一种鸟嘌呤衍生的抗肿瘤药物,可结合并抑制胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的 Ki 分别为 1.3 nM、7.2 nM 和 65 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-01224 | Dihydrofolate reductase Protein, Human, Recombinant (His) | Human | E. coli | ||
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
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TMPH-03535 | Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli | ||
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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TMPH-03581 | Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) | Staphylococcus epidermidis | E. coli | ||
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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