TN5147
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IL Receptor
TNF
GABA Receptor
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Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively. |
T74413
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(S)-Osanetant 是 Osanetant 的S 对映体。Osanetant (SR142801) 是一种选择性的NK3受体拮抗剂。Osanetant 有抗焦虑和抗抑郁的作用,并被研究用于精神分裂症。 |
T69145
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Nisoxetine 是一种有效的和选择性的去甲肾上腺素转运蛋白(NET)抑制剂,Kd 值为 0.76 nM。Nisoxetine 是一种抗抑郁试剂和局部麻药,它可以阻断电压门控性钠通道。 |
T73568
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MTEP,一种非竞争性且高选择性的mGluR5拮抗剂,具有显著的抗抑郁和抗焦虑效果,亦被用于帕金森疾病的研究。 |
T28851
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SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 re |
T62215
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Tandospirone (SM-3997) hydrochloride 是一种高效的、选择性的 5-HT1A 受体部分激动剂 (Ki: 27 nM),表现出抗焦虑和抗抑郁活性。Tandospirone hydrochloride 能够用于研究中枢神经系统疾病及其潜在机制。 |
T79325
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5-HT Receptor
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5-HT6 agonist 1 (Compound 19)为一种5-HT6激动剂 (Ki: 5 nM),展现出抗抑郁样特性并能改善认知缺陷,同时能抑制血小板聚集,具备高代谢稳定性。 |
T60501
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Tipepidine 是一种非麻醉性镇咳药,具有抗抑郁样作用。 Tipepidine 可逆地抑制多巴胺 (DA) D2 受体介导的 GIRK 电流 (IDA(GIRK) ),IC50值为 7.0 μM,随后激活 VTA 多巴胺神经元。 |
TP1992
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Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM. |
T71537
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Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients. |