目录号 | 产品详情 | 靶点 | |
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T70312 | |||
AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA. | |||
T12766 | AChR | ||
RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I. | |||
T77837 | |||
CL2E-SN-38 TFA为一抗体-SN-38稳定偶联体,属抗体药物偶联物(ADC)范畴。SN-38是Irinotecan活性代谢产物,源自喜树碱,作为拓扑异构酶I的抑制剂。 | |||
T73905 | |||
SN-38 glucuronide为Irinotecan这一抗癌活性分子的非活性代谢物。Irinotecan是拓扑异构酶I抑制剂,主要应用于结肠癌及直肠癌的研究。 | |||
T38962 | |||
MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks. | |||
T74491 | |||
Antitumor agent-61 (Compound 9b),Irinotecan (Ir)的衍生物,展现出对多种肿瘤细胞(包括SK-OV-3、SK-OV-3/CDDP、U2OS、MCF-7、A549与MG-63)具有显著的抑制效果,其IC50值分别为0.92、1.39、1.75、2.20、3.05和3.23 μM。该化合物主要通过线粒体途径引发SK-OV-3细胞的凋亡。 | |||
T82231 | |||
hCES2-IN-1(Compound 24)是一种选择性的hCES2可逆抑制剂,其IC50值为6.72 μM。该化合物能够减少活细胞中hCES2的表达量,并且能有效抵抗由Irinotecan引起的迟发性腹泻以及DSS诱发的溃疡性结肠炎。 | |||
T35942 | |||
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable. Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 59 6281 PMID:27259031 | |||
TN1783 | Lipid | ||
Isolicoflavonol 以可逆和混合的方式抑制人羧酸酯酶2介导的荧光素二乙酸酯水解, Ki 小于1.0 μM。 | |||
T82710 | |||
CL2E-SN-38为结构稳定的抗体与SN-38偶联物,属于抗体药物偶联物(ADC)。SN-38作为Irinotecan在喜树碱中的活性代谢产物,充当拓扑异构酶I抑制剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01776 | Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
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TMPY-01690 | Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
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