目录号 | 产品详情 | 靶点 | |
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T36855 | |||
Phomopsinamine is an inhibitor of microtubule polymerization and a derivative of phomopsin A .1It inhibits the rate and extent of polymerization of tubulin isolated from ovine brain (IC50s = 0.53 and 0.59 μM, respectively). 1.Lacey, E., Edgar, J.A., and Culvenor, C.C.Interaction of phomopsin A and related compounds with purified sheep brain tubulinBiochem. Pharmacol.36(13)2133-2138(1987) | |||
T75521 | |||
PM050489 是一种有效的聚酮类微管/微管蛋白 (Microtubule/Tubulin) 抑制剂,可从马达加斯加海绵Lithoplocamia lithistoides 中分离。PM050489 抑制有丝分裂,IC50值为 26.4 nM。PM050489 具有抗肿瘤活性,能用于癌症研究。 | |||
T33892 | |||
PBOX-15 is a novel microtubule-targeting agent that induces apoptosis, upregulates death receptors, and enhances TRAIL-mediated apoptosis in multiple myeloma cells. It also inhibits T cell migration through post-translational modification of tubulin. Pbox | |||
T68570 | |||
TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis. | |||
T73947 | |||
Tubulysin IM-1 是 ADC 细胞毒素 (ADC Cytotoxin), 也是一种微管蛋白结合剂,用作抗微管毒素 (anti-microtubule toxins)。 | |||
T62693 | |||
Tubulin polymerization-IN-29 是一种有效的微管蛋白聚合抑制剂,显示出有效的抗增殖效果。Tubulin polymerization-IN-29 能够诱导 HeLa 细胞的细胞周期阻滞在 G2/M 期。 | |||
T40367 | |||
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor that targets the colchicine-binding site. By inducing tubulin depolymerization, Combretastatin A-1 phosphate tetrasodium inhibits the Wnt/β-catenin pathway and leads to the deactivation of AKT. It possesses both anti-tumor and anti-vascular properties. | |||
T36856 | |||
Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity. Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID:21609844 |Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679 PMID:21700202 | |||
T79629 | |||
Tubulin polymerization-IN-46(compound 9q)是一种微管蛋白抑制剂,能够阻断微管蛋白聚合并诱发细胞凋亡。该化合物通过抑制有丝分裂,导致MCF-7细胞在G2/M期停滞,对MCF-7乳腺癌细胞展现出抗增殖效果,其IC50值为10 nM。 | |||
T60936 | |||
Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的微管蛋白聚合抑制剂,可提高 GTP 水解速率并抑制微管组装。Tubulin aggregation-IN-24 诱导细胞凋亡和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 抑制乳腺癌细胞 MCF-7 的增殖。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00827 | Tau-D Protein, Human, Recombinant (His) | Human | E. coli | ||
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective, and no longer stabilize microtubules properly, it can result in dementias such as Alzheimer's disease and other tauopathies.
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TMPY-03047 | Stathmin 1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and promotion of microtubule depolymerization, which has been implicated in carcinogenesis and aggressive behavior in multiple epithelial malignancies. Stathmin 1 (STMN1) suppression was reported to reduce cellular viability and migration potential. STMN1 may be a promising candidate for targeted therapies in PDAC.
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TMPH-02304 | Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.4 kDa and the accession number is Q86V25.
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TMPY-03509 | TCTP/TPT1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TPT1 has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TPT1 production is thought to be controlled at the translational as well as the transcriptional level.
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