目录号 | 产品详情 | 靶点 | |
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T37670 | |||
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact. | |||
T77264 | |||
Thiocholesterol 是一种胆固醇衍生物,常用于合成阳离子脂质液态晶体 (CLCs)。它也作为纳米银 (SNP) 的有效稳定剂。此外,Thiocholesterol 在质膜研究和药物递送领域有重要应用。 | |||
T38319 | |||
93-O17O is a chalcogen-containing cationic lipidoid.1,2It has been used in the generation of lipid nanoparticles (LPNs). LPNs containing 93-O17O localize to the spleen after intravenous injection into mice.1LPNs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.3,2 1.Zhao, X., Chen, J., Qiu, M., et al.Imidazole-based synthetic lipidoids for in vivo mrna delivery into primary T lymphocytesAngew Chem. Int. Ed. Engl.59(45)20083-20089(2020) 2.Chen, J., Qiu, M., Ye, Z., et al.In situ cancer vaccination using lipidoid nanoparticlesSci. Adv.7(19)eabf1244(2021) 3.Li, Y., Yang, T., Yu, Y., et al.Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteinsBiomaterials178652-662(2018) | |||
T75878 | |||
Catestatin TFA,一个含有21个氨基酸残基、阳离子性疏水性肽,作为内源性肽,调节心脏功能及血压。它通过烟碱型乙酰胆碱受体(nAChRs)以非竞争性方式抑制儿茶酚胺释放,功能为烟碱类拮抗剂。 | |||
T36350 | |||
Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml). | |||
T36357 | |||
Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics. | |||
T74553 | |||
YSK 05是一种对pH敏感的阳离子脂质,能够改善非病毒载体的胞内转运效率。YSK 05-MEND显示出显著的基因沉默活性和溶血性。通过聚乙二醇化处理,YSK 05有效克服了对内体逃逸的抑制,从而在体外和体内均显著增强了siRNA的传递效率。 | |||
T75994 | |||
SPR741 TFA (NAB741 TFA),一种源自多粘菌素B的阳离子肽增效剂,通过提升革兰氏阴性细菌外膜通透性用于对抗重度革兰氏阴性细菌感染。它能够抑制多重耐药性革兰氏阴性细菌,并在与抗生素联用时扩大抗生素的活性谱。 | |||
T39436L | |||
Omiganan aceate (204248-78-2 free base) 是一种阳离子抗菌肽,对革兰氏阳性菌、革兰氏阴性菌以及念珠菌均具有活性。 Omiganan aceate (204248-78-2 Free base) 是吲哚西丁的类似物,用于与酒精鼻和痤疮相关的研究目的。 | |||
T83934 | |||
DMHBO+是一种阳离子荧光团。通过与辣椒适体结合激活其荧光(Kd = 12 nM),形成的Chili-DMHBO+复合体模仿红色荧光蛋白,适用于细胞中RNA的成像。它是理想的FRET供体,可与罗丹明染料Atto 590配合使用,在基于FRET的RNA分析系统中有应用。激发/发射峰值(λ) = 456/592 nm;量子产率 = 0.1;斯托克斯位移 = 136 nm。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00484 | Cationic trypsin Protein, Canine, Recombinant (His & SUMO) | Canine | E. coli | ||
Cationic trypsin Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli.
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TMPJ-00574 | RNASE3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It promotes E. coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
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TMPH-03242 | Anionic trypsin-1 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli | ||
N/A. Anionic trypsin-1 Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 27.2 kDa and the accession number is P00762.
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TMPH-01058 | Cathelicidin antimicrobial peptide Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Cathelicidin antimicrobial peptide Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 24.7 kDa and the accession number is P49913.
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TMPH-03243 | Anionic trypsin-1 Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) | ||
N/A. Anionic trypsin-1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is P00762.
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TMPY-00672 | Azurocidin/CAP37 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Neutrophils arriving first at sites of inflammation release Azurocidin, which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. It thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.
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TMPH-03516 | NPTase Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Highly cationic enzyme that can bind human or rat immunoglobulins as well as serum albumin, and could therefore be involved in post-infectious sequelae. NPTase Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.7 kDa and the accession number is P21222.
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TMPH-02379 | arnT Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
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TMPJ-01243 | DEFB4 Protein, Human, Recombinant | Human | E. coli | ||
Defensins are cationic peptides. It is an important ingredient of the innate immune system. β-defensins are expressed on some leukocytes and epithelial surfaces. Four human β-Defensins have been identified to date: BD-1, BD-2, BD-3 and BD-4. β-defensins contain a six-cysteine motif, they forms three intra-molecular disulfide bonds. β-defensins are also chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors; they are released by proteolytic cleavage of a signal sequence.
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TMPJ-00667 | DEFB4A Protein, Human, Recombinant | Human | E. coli | ||
β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.
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TMPH-01640 | MRGPRX2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
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TMPY-02908 | BPI Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Bactericidal/permeability-increasing protein is a member of the BPI/LBP/Plunc superfamily and BPI/LBP family. It is a cationic protein which can be detected in the azurophilic granule and on the surface of polymorphonuclear leukocytes. Bactericidal/permeability-increasing protein also is a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. Bactericidal/permeability-increasing protein contains two domains that adopt the same structural fold, even though they have little sequence similarity. It binds to and neutralises lipopolysaccharides from the outer membrane of Gram-negative bacteria. The cytotoxic action of bactericidal/permeability-increasing protein is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
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