目录号 | 产品详情 | 靶点 | |
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T78600 | |||
VU0029251为mGluR5部分拮抗剂,表现出对该受体的较高亲和力(Ki: 1.07 μM)。在表达大鼠mGluR5的HEK293细胞膜上,可抑制谷氨酸引起的钙动员(IC50: 1.7 μM)。 | |||
T81242 | |||
RXFP1 receptor agonist-5 (Example 98) 是一种具有高度选择性的RXFP1 受体激动剂,能在稳定表达人RXFP1的HEK293细胞中显著抑制cAMP的产生,其EC50值为1.3 nM。 | |||
T61628 | |||
ERK5-IN-4 (compound 34b) is a powerful and specific inhibitor of extracellular signal-related kinase 5 (ERK5) activity. It effectively inhibits both the full-length ERK5 and the truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with IC50 values of 77 nM and 300 nM, respectively [1]. | |||
T74527 | |||
Anti-MRSA agent 4 (compound 7a) 为针对耐甲氧西林金黄色葡萄球菌 (MRSA) 的革兰氏阳性菌强效选择性生长抑制剂,具有MIC≤ 0.26 µM的显著效力。此外,该化合物在HEK293细胞中未显示细胞毒性和溶血活性。 | |||
T74631 | |||
RNA polymerase II-IN-2 (compound 20iii)是高效的RNA polymerase II (Pol II)抑制剂,其Ki值为74.1 nM。该化合物对癌细胞展现出细胞毒性,其对CHO和HEK293细胞的毒性分别为α-amanitin的2倍和5倍。 | |||
T83743 | |||
VPM-p15是一种合成多肽激动剂,针对粘附G蛋白偶联受体(GPCR) G2 (ADGRG2)而设计,ADGRG2是一种孤儿GPCR,与男性不育有关。在表达人类ADGRG2的HEK293细胞中,它能诱导cAMP积累(EC50 = 1.41 µM)。 | |||
T79913 | |||
GRK2 Inhibitor 2 (Compound 8h) 作为一种高效的抑制剂,对GRK2有显著的抑制活性(IC50: 19 nM),同样对Aurora-A也表现出抑制作用(IC50: 137 nM)。该化合物能增强GRK2过表达的HEK293细胞中β-AR介导的cAMP积累。此外,GRK2 Inhibitor 2适用于充血性心力衰竭(HF)的相关研究。 | |||
T41232 | |||
GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes. | |||
T35906 | |||
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC50 value of approximately 60 μg/ml. | |||
T83674 | |||
K 41498 是一种针对皮质酮释放因子受体2α(CRF2α)和CRF2β的肽拮抗剂,其在表达人类受体的HEK293细胞中的Ki值分别为0.66和0.62 nM。它对CRF2α和CRF2β具有选择性,与CRF1相比(在表达人类受体的HEK293细胞中Ki值为425 nM)。K 41498 (1.84 µg/动物, 静脉注射) 能够阻止大鼠由于尿催肾上腺皮质激素引发的低血压。通过脊髓内给药,K 41498 (0.075-0.5 µmol/动物) 能降低完全弗氏佐剂引起的大鼠模型中机械性爪撤回阈值。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02792 | GDNF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
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TMPY-06985 | NGF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
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TMPY-01920 | BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
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TMPY-01191 | CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766.
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TMPY-04090 | Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa.
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TMPY-01501 | Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His) | H1N1 | HEK293 Cells | ||
Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P03452.
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TMPH-01683 | Tau Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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TMPJ-00895 | SCF Protein, Rat, Recombinant (HEK293, His) | Rat | HEK293 Cells | ||
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
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TMPY-02024 | L-selectin Protein, Human, Recombinant (HEK293,His) | Human | HEK293 Cells | ||
L-selectin Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P14151-1.
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TMPH-00343 | Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) | Canine | HEK293 Cells | ||
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q60FC1.
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TMPJ-01022 | SUMO3 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collectively called SUMO2/3. Several studies suggest that SUMO3 are associated with pathogenesis in several neurological diseases, including Alzheimer's disease, Parkinson's disease, and cerebral ischemia/stroke.
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TMPY-06314 | MMP-10 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
MMP-10 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.38 kDa and the accession number is P09238.
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TMPJ-01163 | CTGF/CCN2 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physiologic conditions. CTGF is pathologically viewed as a central mediator of tissue remodeling and fibrosis of various organs, including the lung, heart, liver, and kidney.
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TMPH-00743 | PhoP Protein, E. coli, Recombinant (HEK293, His & Myc) | E. coli | HEK293 Cells | ||
Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.
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TMPY-02167 | Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) | Mouse | HEK293 Cells | ||
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2.
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TMPJ-00716 | Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.
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TMPY-05683 | SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.54 kDa and the accession number is A0A6G7K2L4.
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TMPJ-00386 | ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated | Human | HEK293 Cells | ||
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
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TMPY-05661 | SARS-CoV-2 Spike S1 Protein (HEK293, His) | HEK293 Cells | |||
SARS-CoV-2 Spike S1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The accession number is A0A6G7K2L4.
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TMPY-05719 | SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 28.36 kDa and the accession number is A0A6G7K2L4.
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TMPY-03800 | Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa.
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TMPY-05932 | Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His) | H1N1 | HEK293 Cells | ||
Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.2 kDa and the accession number is A0A0G3XQY1.
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TMPY-03840 | Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa.
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TMPY-00549 | Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) | H5N1 | HEK293 Cells | ||
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is B7NWR4.
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TMPY-00595 | Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) | H5N1 | HEK293 Cells | ||
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is B7NWR4.
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TMPY-06987 | Wnt Surrogate/Wnt3a Protein, Recombinant | Human | HEK293 Cells | ||
Wnt Surrogate/Wnt3a Protein, Recombinant is expressed in HEK293 mammalian cells with hFc tag.
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TMPY-05573 | CD38 Protein, Human, Recombinant (His), PE conjugated | Human | HEK293 Cells | ||
CD38 Protein, Human, Recombinant (His), PE conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
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TMPY-00608 | TGF beta 1 Protein, Rat/Mouse, Recombinant | Mouse,Rat | HEK293 Cells | ||
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
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TMPY-05072 | IgE Fc Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IgE Fc Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa.
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TMPY-04845 | IL-3 Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
IL-3 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.7 kDa and the accession number is P01586.
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TMPY-00167 | HER2/ERBB2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
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TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
IL-1R2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.4 kDa and the accession number is P27930-1.
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TMPY-00748 | Nectin-2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
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TMPY-03466 | PLGF/PGF Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
PLGF/PGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.6 kDa and the accession number is P49764.
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TMPY-00443 | EPO/Erythropoietin Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
EPO/Erythropoietin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.6 kDa and the accession number is P07321.
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TMPY-01919 | MMP-9 Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
MMP-9 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 78.4 kDa and the accession number is P41245-1.
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TMPY-03467 | IFN-beta Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575.
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TMPY-05202 | Noggin/NOG Protein, Human, Recombinant | Human | HEK293 Cells | ||
Noggin/NOG Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.1 kDa and the accession number is Q13253.
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TMPY-04829 | G-CSF Protein, Human, Recombinant | Human | HEK293 Cells | ||
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
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TMPY-04832 | OX40L/TNFSF4 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
OX40L/TNFSF4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.6 kDa.
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TMPY-02694 | IgG2a Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
IgG2a Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.4 kDa and the accession number is P01863.
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TMPY-05566 | Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) | Human | HEK293 Cells | ||
Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) is expressed in HEK293 mammalian cells with His tag. The accession number is P20273-1.
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TMPY-04018 | LRG1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
LRG1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.1 kDa and the accession number is AAH34389.1.
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TMPY-03890 | CD81 Protein, Human, Recombinant | Human | HEK293 Cells | ||
CD81 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 9.9 kDa and the accession number is A0A024RCB7.
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TMPY-03357 | FGFR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FGFR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is AAA39377.1.
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TMPY-05679 | SARS-CoV-2 Spike RBD Protein (hFc) | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (hFc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 51.8 kDa and the accession number is A0A6G7K2L4.
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TMPY-01008 | VEGFD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
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TMPY-05047 | CD44 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD44 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.6 kDa and the accession number is Q3U8S1.
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TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1.
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TMPY-04925 | CD8 beta Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells | ||
CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1.
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