目录号 | 产品详情 | 靶点 | |
---|---|---|---|
TN2688 | Antioxidant Lipoxygenase | ||
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 是一种天然产物,可从 Parinari hypochrysea (Chrysobalanaceae) 中提取得到。2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 具有抗氧化活性且对脂氧合酶具有抑制作用。 | |||
T71322 | |||
CV 6504 is a dual inhibitor of thromboxane A2 synthetase and 5-lipoxygenase. It also possesses oxygen scavenging activity. | |||
T14343 | Others | ||
Atreleuton (ABT-761) is a potent and selective inhibitor of leukotriene formation[1][2][3]. As a reversible and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor, Atreleuton (ABT-761) exhibits selectivity. | |||
T13295 | LTR | ||
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4. | |||
T24307 | |||
L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro. It also inhibits the synthesis of the products of both these pathways in whole cells. | |||
T25377 | |||
EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. | |||
T19574 | Others | ||
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid)是一种溴代芳香族化合物。它被发现可以抑制环氧合酶-2(COX-2)、脂氧合酶(LOX)、5-脂氧合酶类(5-LOX)、5-α还原酶和酪氨酸酶等,具有多种抗炎作用和抗氧化作用。 | |||
T71397 | |||
Setileuton, also known as MK0633, is a potent and selective 5-lipoxygenase inhibitor which is under investigation for the treatment of asthma and atherosclerosis. | |||
T70563 | |||
KC-11404 is an LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor and 5-lipoxygenase. | |||
T70612 | |||
E 3040 is a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase. It is involved with eicosanoid production. E 3040 also has anti-inflammatory properties. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-01481 | FLAP Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. In addition, the protein FLAP has recently been identified as an emerging target in metabolic disease. In fact, FLAP is overexpressed in the adipose tissue of patients and experimental animals with obesity.
|
|||||
TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 Cells | ||
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
|
|||||
TMPY-05387 | SLAMF7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
|
|||||
TMPY-04318 | GRIK2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 has a role in the maintenance of urothelial CSCs/CICs and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas.
|
|||||
TMPY-05547 | SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells | ||
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
|
|||||
TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death Associated Protein 6.
|
|||||
TMPY-05498 | SR-BI/SCARB1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
|
|||||
TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
|
|||||
TMPK-01363 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40 kDa and the accession number is P78324 variant 5.
|