目录号 | 产品详情 | 靶点 | |
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T9928 | VEGFR | ||
Ranibizumab 是一种人源化单克隆抗体片段,旨在靶向和抑制血管内皮生长因子 (VEGF),包括 VEGF110、VEGF121 和 VEGF165。 Ranibizumab 选择性靶向和中和 VEGF-A 同工型的能力使其成为湿性年龄相关性黄斑变性 (AMD) 研究和治疗策略的重要组成部分。 | |||
T3691 | VEGFR | ||
(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂,其IC50=23 nM。 | |||
T3569 | VEGFR Tyrosinase | ||
SU5214 (SU 5214) 是 VEGFR2 抑制剂,IC50值为 14.8 µM(FLK-1) 和 36.7 µM (EGFR)。 | |||
T6517 | VEGFR c-Met/HGFR | ||
Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。 | |||
T3599 | VEGFR | ||
BFH772 是 VEGFR2抑制剂(IC50:3 nM),具有口服活性。 | |||
T5466 | VEGFR FGFR FLT PDGFR | ||
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。 | |||
T21593 | VEGFR | ||
AAL-993 是口服有效的VEGFR 选择性抑制剂,抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM,对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。 | |||
T7123 | VEGFR p38 MAPK JAK Src | ||
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
T2906 | VEGFR | ||
Tanshinone IIA (Tanshinone B) 是红根丹参根系中的一种主要组合物。它能够利用靶向 VEGF/VEGFR2的蛋白激酶结构域,抑制血管生成。 | |||
T6996 | VEGFR FGFR PDGFR | ||
SU 5402 是多靶点受体酪氨酸激酶抑制剂,能够抑制VEGFR2 (IC50:20 nM),FGFR1 (IC50:30 nM),PDGFRβ (IC50:510 nM)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03156 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) | Mouse,Rat | HEK293 Cells | ||
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.5 kDa and the accession number is P97953-1.
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TMPY-03698 | VEGF121b Protein, Human, Recombinant | Human | HEK293 Cells | ||
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
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TMPY-02432 | VEGF164 Protein, Rat, Recombinant | Rat | Baculovirus Insect Cells | ||
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2.
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TMPY-04911 | VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated | Human,Cynomolgus | HEK293 Cells | ||
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
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TMPY-00930 | TIE2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
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TMPY-01064 | TIE2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
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TMPY-01008 | VEGFD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
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TMPJ-00864 | VEGF165 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimulates the cellular response through binding to tyrosine kinase receptors VEGFR1 and VEGFR2 on the cell surface. It is widely accepted that VEGFR2 mediate almost all of the known cellular responses to VEGF while the function of VEGFR1 is less defined and is thought to modulate the VEGFR2 signaling.
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TMPY-01717 | VEGF164 Protein, Mouse, Recombinant | Mouse | Baculovirus Insect Cells | ||
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
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TMPY-00970 | CD31/PECAM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD31/PECAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is EAW94208.1.
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TMPY-01007 | VEGFC Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is P49767.
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TMPJ-00865 | VEGF121 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessels and endothelial cell growth, increasing microvascular permeability, promoting cell migration and inhibiting apoptosis. Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
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TMPJ-00603 | TL1A/TNFSF15 Protein, Mouse, Recombinant | Mouse | E. coli | ||
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
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TMPY-02745 | ESAM Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
ESAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is Q6AYD4.
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TMPY-02508 | TIE2 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
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TMPY-03347 | EPCR Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
EPCR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.2 kDa.
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TMPY-05049 | TIE2 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
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TMPY-00798 | ESAM Protein, Human, Recombinant | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is Q96AP7-1.
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TMPY-01312 | ESAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is Q96AP7-1.
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TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinase domain. VEGFR-1is an essential receptor tyrosine kinase and plays an important role in theregulation of VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. It is also mediators of neurotrophic activity and regulators of hematopoietic development. VEGFR-1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF.It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells and promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. VEGFR-1 can also promote PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
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TMPY-03832 | EPCR Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
EPCR Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is XP_001100647.1.
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TMPY-03563 | TIE2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68.
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TMPY-03594 | EPCR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
EPCR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa.
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TMPY-00797 | ESAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q96AP7-1.
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TMPY-00624 | PEAR1 Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
Platelet endothelial aggregation receptor-1 (PEAR1), an epidermal growth factor repeat-containing transmembrane receptor, is known to participate in platelet contact-induced activation. Platelet endothelial aggregation receptor 1 (PEAR1) triggers platelet aggregation and is expressed in platelets and endothelial cells.PEAR1 encodes the Platelet-Endothelial Aggregation Receptor 1, a contact receptor involved in platelet function and megakaryocyte and endothelial cell proliferation. PEAR1 expression during megakaryocyte differentiation is controlled by DNA methylation at its first CpG island.
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TMPY-03155 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) | Mouse,Rat | HEK293 Cells | ||
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 41.5 kDa and the accession number is O35757.
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TMPY-03887 | ESM1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
ESM1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.6 kDa and the accession number is Q9NQ30-1.
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TMPY-03192 | EPCR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
EPCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is AAH14451.1.
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TMPY-02715 | EPCR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
EPCR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is Q9UNN8.
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TMPY-02734 | ESAM Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ESAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is Q925F2.
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TMPY-03230 | ESM1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
ESM1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.17 kDa and the accession number is Q9QYY7.
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TMPY-02487 | EPCR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
EPCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q64695.
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TMPY-02489 | EPCR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
EPCR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is Q64695.
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TMPY-04545 | TIE2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1.
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TMPY-03080 | VEGF165 Protein, Danio rerio (zebrafish), Recombinant | Danio rerio (zebrafish) | Baculovirus Insect Cells | ||
VEGF165 Protein, Danio rerio (zebrafish), Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is O73682.
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TMPY-03705 | VEGF164 Protein, Canine, Recombinant | Canine | HEK293 Cells | ||
VEGF164 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9MYV3-3.
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TMPY-03200 | VEGFD Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
VEGFD Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is O35251.
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TMPY-04327 | VEGFB Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang II-induced rising in Ca2+.
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TMPY-05244 | TIE2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
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TMPH-01113 | COL8A1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
COL8A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPY-04575 | TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) | Mouse | Baculovirus Insect Cells | ||
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.
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TMPY-01954 | TIE2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8.
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TMPY-06974 | TIE2 Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells | ||
TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858.
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TMPJ-01333 | TEM8/ANTXR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It is also involved in the angiogenic response of cultured umbilical vein endothelial cells, up-regulated in cultured angiogenic umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI).
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TMPY-01619 | CD31/PECAM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD31/PECAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is Q03311.
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TMPY-02983 | LYVE1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
LYVE1, also known as LYVE-1, is a type I integral membrane glycoprotein. It contains 1 Link domain and is mainly expressed in endothelial cells lining lymphatic vessels. LYVE1 acts as a receptor and binds to both soluble and immobilized hyaluronan. It may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE1 also is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. It also functions as a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding. It may act as a hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
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TMPJ-00564 | PLXDC2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Mouse Plexin domain-containing protein 2(PLXDC2) is a single-pass type I membrane protein. The protein is expressed in tumor endothelium and in vessels of some normal tissues, such as the muscle and lung. PLXDC2 can interact with CTTN, and may play a role in tumor angiogenesis.
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TMPJ-00625 | Serpin E1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
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TMPY-01656 | VEGF183 Protein, Human, Recombinant | Human | Baculovirus Insect Cells | ||
VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3.
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TMPY-00707 | CD31/PECAM-1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
CD31/PECAM-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 65.1 kDa and the accession number is EAW94208.1.
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