T14530
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Benzenedimethanamine-diethylamine
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Benzenedimethanamine-diethylamine is a derivatized linker compound derived from an alkyl chain. It serves as a valuable component in the synthesis of PROTACs, a class of compounds used for targeted protein degradation[1].
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T18864
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UAA crosslinker 1
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UAA crosslinker 1 hydrochloride is an Amber codon-activating agent utilized for the incorporation of non-canonical amino acids (ncAAs) into proteins. This incorporation is achieved in vivo by leveraging the promiscuous activity of specific wildtype and engineered aminoacyl-tRNA synthetases[1].
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T18113
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m-PEG-Tresyl (MW 5000)
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m-PEG-Tresyl (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T15989
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Mal-PEG4-acid
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Mal-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T18299
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Mal-PEG8-Val-Cit-PAB-MMAE
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Mal-PEG8-Val-Cit-PAB-MMAE is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
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T18251
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MAL-di-EG-Val-Cit-PAB-MMAF
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MAL-di-EG-Val-Cit-PAB-MMAF refers to a chemical compound that comprises the linker (MAL-di-EG-Val-Cit-PAB) and the potent blocker of tubulin polymerization (MMAF, Monomethyl auristatin F)[1].
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T14402
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Azido-PEG1-amine
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Azido-PEG1-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T13990
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1,3-Bis-aminooxy propane
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1,3-Bis-aminooxy propane is an alkyl chain-derived PROTAC linker utilized for synthesizing PROTACs[1].
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T18652
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RTC-30
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RTC-30 is an optimized phenothiazine compound possessing potent anti-cancer properties. It is formulated with a hydroxylated linker (N) which enhances its oral bioavailability[1].
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T17141
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Tos-PEG9
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Tos-PEG9 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T18322
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MC-Val-Cit-PAB-clindamycin
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MC-Val-Cit-PAB-clindamycin is an antibody-drug conjugate (ADC) linker that combines the potent antitumor properties of clindamycin, a protein synthesis inhibitor, with the ADC linker MC-Val-Cit-PAB, to enhance its ability to target and kill cancer cells effectively.
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T16316
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NH2-PEG6-CH2CH2COOH
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NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
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T17084
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THP-PEG6-OH
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THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2].
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T15522
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Hydroxy-PEG3-acrylate
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Hydroxy-PEG3-acrylate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T14712
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Boc-Aminooxy-PEG3-acid
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Boc-Aminooxy-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T15929
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m-PEG8-Br
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m-PEG8-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T17767
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DBCO-NHCO-PEG2-NHS ester
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DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].
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T14099
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Acid-PEG2-C2-Boc
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Acid-PEG2-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T17380
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Ald-Ph-amido-PEG1-C2-Pfp ester
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Ald-Ph-amido-PEG1-C2-Pfp ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.
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T18237
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Mal-amido-PEG12-NHS ester
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Mal-amido-PEG12-NHS ester is a polyethylene glycol (PEG)-derived linker for proteolysis-targeting chimeras (PROTACs)[1]. It is employed in the synthesis of PROTACs, enabling the conjugation of desired target-specific ligands for protein degradation[1].
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