目录号 | 产品详情 | 靶点 | |
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T22036 | |||
Arylquin 1 是一种前列腺-凋亡-反应-4(Par-4)促分泌剂,靶向波形蛋白诱导 Par-4 分泌。Arylquin 1 通过诱导溶酶体膜通透性 (LMP) 诱导癌细胞非凋亡性细胞死亡。 | |||
T78099 | |||
iso-TRAP-6(iso-SFLLRN)为PAR-1激动剂,具备激活血小板的能力。该化合物作为TRAP-6的同系物,通过以异丝氨酸替换丝氨酸成为首位氨基酸而构成。 | |||
T80239 | Thrombin | ||
TFLLRNPNDK-NH2 是具备生物活性的肽类化合物,作为凝血酶受体激活肽(PAR-1 激动剂肽)能够可逆地与 PAR-1 结合,模拟凝血酶对底物蛋白通过水解作用产生的“束缚配体”。同凝血酶的作用相似,此肽能够增加液体与蛋白质的渗透性。 | |||
T80111 | |||
TRAP-5 amide为蛋白酶激活受体1(PAR1)特异性的激动剂肽。 | |||
T62507 | |||
Protease-Activated Receptor-1 antagonist 1 (Compound 13) 是一种蛋白酶激活受体 1 (PAR-1) 拮抗剂,通过 FLIPR 技术得到的 IC50 为 3 nM。Protease-Activated Receptor-1 antagonist 1 能够用于研究血栓性心血管、心肌梗塞和外周动脉疾病。 | |||
T80502 | |||
P4pal10为PAR4拮抗剂,能在体内抑制凝血酶介导的小鼠血小板聚集,并显著减少Carrageenan引起的水肿及粒细胞浸润。 | |||
T27708 | |||
K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8. | |||
T64285 | |||
Protease-Activated Receptor-1 antagonist 2 是一种选择性的、口服具有活力的蛋白酶激活受体-1 (PAR-1) 拮抗剂 (IC50: 7 nM)。Protease-Activated Receptor-1 antagonist 2 显示出良好的药代动力学特性,能够用于进行心血管疾病 (CVD) 的相关研究(如动脉粥样硬化和再狭窄)。 | |||
T39785 | |||
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation. | |||
T74266 | |||
Protease-Activated Receptor-1 antagonist 2 是一种选择性蛋白酶激活受体-1 (PAR-1) 拮抗剂,口服活性,IC50值为7 nM。该化合物具有优良的药代动力学特性,适用于心血管疾病 (CVD) 如动脉粥样硬化和再狭窄的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01257 | uPAR/PLAUR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
uPAR/PLAUR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is P35456-1.
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TMPY-02141 | uPAR/PLAUR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
uPAR/PLAUR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q03405-1.
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TMPY-01017 | uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 58 kDa and the accession number is P35456-1.
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TMPY-05025 | Thrombin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7.
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TMPK-00228 | uPAR/PLAUR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 58.2 kDa and the accession number is Q03405-1.
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TMPK-00215 | uPAR/PLAUR isoform 1 Protein, Mouse, Recombinant (His & Avi) | Mouse | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR isoform 1 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.92 kDa and the accession number is P35456-1.
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TMPK-00216 | uPAR/PLAUR Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.92 kDa and the accession number is P35456-1.
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TMPK-00227 | uPAR/PLAUR Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.36 kDa and the accession number is Q03405-1.
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TMPK-00226 | uPAR/PLAUR Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.36 kDa and the accession number is Q03405-1.
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TMPK-01175 | uPAR/PLAUR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.69 kDa and the accession number is Q9GK78.
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TMPY-03596 | JTB Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
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TMPY-06150 | Par j 2 Protein, Parietaria judaica, Recombinant (His) | Parietaria judaica | HEK293 Cells | ||
Par j 2 is one of the major allergens of the Parietaria judaica. Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. The major allergens from P. judaica pollen, Par j 1 and Par j 2, have amino acid sequence identity of 45% and contain eight cysteine residues involved in disulphide bonds that compact the structure.
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