目录号 | 产品详情 | 靶点 | |
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T38352 | |||
Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function. | |||
T78582 | Prostaglandin Receptor | ||
15-keto-Prostaglandin E2为内源性代谢产物,通过与STAT3Cys259残基结合,抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体,进而抑制乳腺癌细胞生长与进展,并通过激活PPAR-γ促进真菌生长。 | |||
T75448 | |||
Aculene D, 一种真菌代谢物,针对Chromobacterium violaceum CV026表现出群体感应(QS)抑制活性。该化合物能在亚抑制浓度下,显著削减由N-己酰基-l-高丝氨酸内酯(C6-HSL)触发的C. violaceum CV026培养物中紫罗兰素的产生。 | |||
T37609 | |||
Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3 References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). | |||
T78112 | |||
Voxvoganan (LTX-109) trihydrochloride为有效的局部抗菌剂,特别是针对S. aureus,其MIC为2-4 μg/mL。该化合物主要用于研究细菌性皮肤感染和真菌感染。 | |||
T38086 | |||
Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae fungi. | |||
T35483 | |||
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. | |||
T37552 | |||
(+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner. (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 μg/ml, respectively), but not Gram-negative bacteria or fungi. | |||
T37442 | |||
Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM). | |||
T37752 | |||
Aureonitol is a fungal metabolite that has been found inChaetomiumand has antiviral activity.1It inhibits replication of the influenza A subtype H3N2 with an EC50value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC50s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC50= 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1. 1.Sacramento, C.Q., Marttorelli, A., Fintelman-Rodrigues, N., et al.Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutininPLoS One10(10)e0139236(2015) |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for the induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defense while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
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TMPH-03738 | Endochitinase B Protein, Zea mays, Recombinant (His & Myc) | Zea mays | E. coli | ||
Defense against chitin-containing fungal pathogens.
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TMPH-00121 | Antifungal Protein, Aspergillus giganteus, Recombinant (B2M & His) | Aspergillus giganteus | E. coli | ||
This protein inhibits the growth of a variety of fungal species. Antifungal Protein, Aspergillus giganteus, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 19.8 kDa and the accession number is P17737.
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TMPH-00135 | Endochitinase Protein, Avena sativa, Recombinant (His) | Avena sativa | E. coli | ||
This protein functions as a defense against chitin-containing fungal pathogens. Endochitinase Protein, Avena sativa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.7 kDa and the accession number is P86181.
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TMPH-00819 | Pro-hevein Protein, Hevea brasiliensis, Recombinant (His) | Hevea brasiliensis | E. coli | ||
N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin. Can inhibit fungal growth. Pro-hevein Protein, Hevea brasiliensis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.1 kDa and the accession number is P02877.
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TMPH-00035 | Polyphenol oxidase 2 Protein, Agaricus bisporus, Recombinant (His) | Agaricus bisporus | Baculovirus Insect Cells | ||
Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores.
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TMPH-03231 | AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) | Raphanus sativus | E. coli | ||
Possesses antifungal activity sensitive to inorganic cations. Induces potential changes in fungal membranes and increased K(+) efflux and Ca(2+) uptake. AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.7 kDa and the accession number is P30230.
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TMPH-00761 | Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant | Neocosmosporum cucurbitae | E. coli | ||
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.4 kDa and the accession number is Q99174.
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TMPH-00424 | Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO) | Colletotrichum capsici | E. coli | ||
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.0 kDa and the accession number is P10951.
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TMPH-00760 | Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) | Neocosmosporum cucurbitae | P. pastoris (Yeast) | ||
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is Q99174.
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TMPY-05009 | Asp f 1 Protein, Neosartorya fumigata, Recombinant (His) | Neosartorya fumigata | HEK293 Cells | ||
Asp f 1 (Aspergillus fumigatus allergen 1) is a major allergen produced by the mycelia of Aspergillus fumigatus. It is not present in spores and can be used as a specific marker for the detection of germination of this fungus. Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically complex allergic disorder caused by the fungal pathogen Aspergillus fumigatus.
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TMPH-00331 | ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) | Candida albicans | E. coli | ||
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) is expressed in E. coli expression system with N-10xHis-B2M and C-Myc tag. The predicted molecular weight is 37.9 kDa and the accession number is O74623.
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TMPJ-01440 | Cutinase Protein, Thermobifida fusca, Recombinant (His) | Thermobifida fusca | E. coli | ||
Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5 helices on either side of the sheet. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can greatly increase the amount of cutinase secreted by the spore. The active site cleft is partly covered by 2 thin bridges formed by amino acid side chains, by contrast with the hydrophobic lid possessed by other lipases. The protein also contains 2 disulfide bridges, which are essential for activity, their cleavage resulting in complete loss of enzymatic activity.
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