目录号 | 产品详情 | 靶点 | |
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T0868 | Antibacterial Antibiotic Antifection | ||
Cefepime Dihydrochloride Monohydrate (Cefepime HCl) 是一种广谱头孢菌素,对革兰氏阳性菌和革兰氏阴性菌有更高的覆盖率。 | |||
T6268 | Antibacterial Antibiotic | ||
Ceftiofur hydrochloride (U-67279A) 是头孢噻呋的盐酸盐形式,是一种β-内酰胺酶稳定的半合成广谱头孢菌素,具有抗菌活性。 | |||
T13038 | Antibacterial Antibiotic | ||
Sultamicillin 是一种具有口服活性的氨苄西林/舒巴坦双前药。它是一种半合成 β-内酰胺酶抑制剂。 | |||
T17210L | Antibacterial | ||
Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂,可以恢复碳青霉烯类药物对 KPC 生产菌株的活性,常与其它药物连用来研究真菌感染。 | |||
T1405 | Antibacterial Antibiotic | ||
Cefditoren pivoxil (ME 1207) 是一种半合成、广谱、β-内酰胺酶耐药的第三代头孢菌素抗生素,具有杀菌活性。 | |||
T23858 | Antibacterial | ||
WCK-5153 是 β-Lactamase 的增强剂和 PBP2 的抑制剂,对铜绿假单胞菌具有抗菌活性。 WCK-5153 可用于治疗由高度耐药的革兰氏阴性病原体引起的严重感染的研究。 | |||
T23801 | Antibacterial | ||
WCK-4234 sodium (WCK 4234) 是一种 β-内酰胺酶抑制剂,可用于针对 MDR 感染的研究。 WCK-4234 sodium 抑制 A、C 和 D 类 β-内酰胺酶和 OXA 碳青霉烯酶。 | |||
T13077 | Antibacterial Antifungal | ||
Taniborbactam dihydrochloride (VNRX-5133 dihydrochloride) 是一种具有选择性和有效性的新型环硼酸β-内酰胺酶抑制剂,具有抗菌活性,对革兰氏阴性菌抑制作用显著。Taniborbactam dihydrochloride 抑制 KPC-2,AmpC,OXA-48 和 VIM-2 ,可以用于研究真菌感染。 | |||
T60050 | Antibacterial | ||
ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂,对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。 | |||
T19860 | Antibacterial Antifungal | ||
Clavulanic Acid(RX-10100) 是一种由生物体克拉维链霉菌产生的主要β-内酰胺类抗生素,是一种强效的细菌 β-内酰胺酶抑制剂,用于研究细菌引起的感染。Clavulanic Acid 具有广谱的生物活性,对多种革兰氏阳性和革兰氏阴性细菌均有活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00588 | Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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TMPH-00584 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli with N-terminal 6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa. Accession number: P24735
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TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Hydrolyzes both carbenicillin and oxacillin.
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TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | Yeast | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-03474 | Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant | Salmonella typhimurium | E. coli | ||
Has cefotaxime-hydrolyzing activity.
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TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | Yeast | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPJ-01157 | LACTB2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is expressed at high levels and annotates structural defects or features in 4 cDNA clones. LACTB2 proteins are expected to have hydrolase activity and metal ion-binding functions. LACTB2 protein is found to localize in mitochondrion. Other functions of LACTB2 is yet unknown.
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TMPH-00019 | BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) | Acinetobacter baumannii | E. coli | ||
BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) is expressed in E. coli with N-terminal 6xHis-SUMO tag. The predicted molecular weight is 22.0 kDa. Accession number: F8UNN7
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TMPH-03602 | BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) | Streptomyces clavuligerus | E. coli | ||
BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
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TMPY-02288 | Glyoxalase II/HAGH Protein, Human, Recombinant (His) | Human | E. coli | ||
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathione Hydrolase Deficiency. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Metabolism. The human and rodent forms of glyoxalase II (HAGH) can readily be separated by starch gel electrophoretic procedures.
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TMPH-02998 | Porin MspA Protein, Mycobacterium smegmatis, Recombinant (His) | Mycobacterium smegmatis | E. coli | ||
The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA channels into the membrane or by the existence of different MspA conformations.
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TMPY-02447 | Shiga toxin II subunit B Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregative Shiga-toxin–producing E. coli O104:H4, producing extended-spectrum beta-lactamase. The toxin has two subunits—A and B. E. Coli STX2B is the B subunit. It is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide. Following this, the A subunit is internalised and cleaved into two parts. Stx2 has been found to be approximately 400 times more toxic (as quantified by LD50 in mice) than Stx-1. The Stx1 and Stx2 B subunits form a pentameric structure that binds to globotriaosylceramide receptors on eukaryotic cells and promotes endocytosis.
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