目录号 | 产品详情 | 靶点 | |
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T78914 | |||
S-F24是一种抗真菌剂,显示出优异的广谱性(fungal)。该化合物在抑制CYP3A4方面的IC50为0.4 μM,表现出良好的安全性和高选择性,同时具有低溶血活性及较低的诱导耐药性。S-F24适用于真菌感染研究。 | |||
T74527 | |||
Anti-MRSA agent 4 (compound 7a) 为针对耐甲氧西林金黄色葡萄球菌 (MRSA) 的革兰氏阳性菌强效选择性生长抑制剂,具有MIC≤ 0.26 µM的显著效力。此外,该化合物在HEK293细胞中未显示细胞毒性和溶血活性。 | |||
T71266 | |||
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline. | |||
T76468 | |||
Cecropin A (1-7)-Melittin A (2-9) 为一种具抗菌效能的肽,对广谱革兰氏阳性及革兰氏阴性需氧菌显示出显著的抗菌活性,同时展现出抗疟能力,而无蜂毒肽所致的不良溶血现象。 | |||
T75582 | |||
Naja Melanoleuca Venom (Forest Cobra Venom) 是一种蛇毒,可从 Naja Melanoleuca 获得。Naja Melanoleuca Venom 对人类红细胞具有溶血活性。α-神经毒素可以从 Naja Melanoleuca 毒液中分离出来,并抑制 GABAA 受体功能。 | |||
T80365 | |||
Maximin H39为一种抗菌肽,对C. albicans、S. aureus、B. subtilis展示抗菌活性(MIC: 9.4, 9.4, 18.8 μg/mL),且对人类及兔子红细胞具溶血活性。 | |||
T80369 | |||
Maximin 68为抗菌肽,其对C. albicans、S. aureus、E. coli、B. subtilis显示出抗菌活性(MIC分别为18.8、9.4、37.5、9.4 μg/mL),并对人和兔红细胞表现出溶血活性。 | |||
T78935 | |||
Quorum Sensing-IN-2(compound 23e)是一款不影响细菌生长的群体感应抑制剂,具有减少细菌致病性的功能。该化合物在抑制细菌感染方面表现出效力,同时具有极低的溶血活性。在铜绿假单胞菌PAO1引起的菌血症模型中,Quorum Sensing-IN-2与环丙沙星共同作用,显示了协同效应。 | |||
T36439 | Antibacterial HIF Parasite | ||
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin A 具有抗菌、抗疟活性以及溶血活性。 | |||
T74553 | |||
YSK 05是一种对pH敏感的阳离子脂质,能够改善非病毒载体的胞内转运效率。YSK 05-MEND显示出显著的基因沉默活性和溶血性。通过聚乙二醇化处理,YSK 05有效克服了对内体逃逸的抑制,从而在体外和体内均显著增强了siRNA的传递效率。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01075 | Von Willebrand Factor/vWF Protein, Human, Recombinant (His) | Human | CHO Cells | ||
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.
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TMPH-00512 | Lysenin-related protein 2 Protein, Eisenia foetida, Recombinant (His & Myc) | Eisenia fetida | E. coli | ||
Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. It also has antibacterial activities against B.megaterium.
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TMPH-00636 | Hemolysin E, chromosomal Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
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TMPH-03556 | HlgC Protein, S. aureus, Recombinant (E. coli, His) | Staphylococcus aureus | E. coli | ||
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgC Protein, S. aureus, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.6 kDa and the accession number is Q7A3S2.
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TMPH-03557 | HlgC Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | P. pastoris (Yeast) | ||
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgC Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.6 kDa and the accession number is Q7A3S2.
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TMPH-03554 | HlgB Protein, S. aureus, Recombinant (E. coli, His) | Staphylococcus aureus | E. coli | ||
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgB Protein, S. aureus, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.1 kDa and the accession number is P0A075.
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TMPH-00173 | Subtilosin-A Protein, Bacillus subtilis, Recombinant (His & KSI) | Bacillus subtilis | E. coli | ||
Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium. A single mutation (Thr-14-Ile) confers hemolytic activity against rabbit and human blood. Subtilosin-A Protein, Bacillus subtilis, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.8 kDa and the accession number is O07623.
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TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli | ||
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
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TMPH-03555 | HlgB Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | P. pastoris (Yeast) | ||
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgB Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P0A075.
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TMPJ-01306 | CFHR5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
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TMPJ-01034 | TIM Protein, Human, Recombinant (His) | Human | E. coli | ||
Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants, and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI. TPI plays an important role in glycolysis and is essential for efficient energy production. TPI deficiency is an autosomal recessive disorder and the most severe clinical disorder of glycolysis. Triose phosphate isomerase deficiency is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection and characterized by chronic hemolytic anemia.
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TMPH-03553 | HlgA Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli | ||
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgA Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is P0A073.
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TMPH-00037 | Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His) | Aggregatibacter actinomycetemcomitans | P. pastoris (Yeast) | ||
Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 38.3 kDa and the accession number is P16462.
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TMPH-03035 | M-myrmeciitoxin-Mp2b Protein, Myrmecia pilosula, Recombinant (GST & His) | Myrmecia pilosula | Baculovirus Insect Cells | ||
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2.18 uM). In vivo, shows moderate insecticidal activity against D.melanogaster and potent anthelmintic activity against the veterinary nematode H.contortus. In addition, intraplantar injection into mice induces nocifensive behavior and mechanical allodynia.
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TMPJ-00800 | BPGM Protein, Human, Recombinant (His) | Human | E. coli | ||
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells for oxygen and result in hemolytic anemia.
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TMPY-02023 | CD46 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
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TMPJ-00836 | G6PD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). G6PD produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. It is notable in humans that G6PD is remarkable for its genetic diversity. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.
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TMPJ-00979 | GSH-S Protein, Human, Recombinant (His) | Human | E. coli | ||
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in Glutathione Synthetase can also cause the glutathione synthetase deficiency of erythrocytes, which is a mild form causing hemolytic anemia.
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TMPY-02835 | DEFB103A Protein, Human, Recombinant (His) | Human | E. coli | ||
Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. Beta-defensin 3 shows antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Beta-defensin 3 is abundantly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. It is also expressed in salivary gland, bone marrow, colon, stomach, polyp and larynx. However, in small intestine, it cannot be detected. Defensin has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. Beta-defensin 3 kills multiresistant S.aureus and vancomycin-resistent E.faecium. It has no significant hemolytic activity.
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