T63478
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Antifungal agent 12 是新型的 fluconazole 类化合物,表现出良好的抗真菌效果。 |
T63157
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Antifungal agent 16 的抗菌活性与环丙沙星相当,且抗真菌活性高于氟康唑。 |
T68562
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FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains). They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteristic of these drugs. |
T63802
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Antifungal agent 35 是一种使氟康唑对C. albicans 的抗真菌活性的有效增强剂,是有效的抗真菌剂。 |
T79384
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Antifungalagent 72(Compound B8)是一款高效抗真菌药物。该化合物通过抑制Pdr1-KIX相互作用(Ki:11.7μM)来干扰外排泵功能,并降低与耐药性相关的基因表达。Antifungalagent 72对抗氟康唑(Fluconazole)耐药的C. glabrata 0161菌株显示出显著的抗菌活性,其MIC值为63 ng/mL,并与氟康唑合用时表现出协同效果。此化合物可应用于C. glabrata感染的相关研究。 |
T61188
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Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1]. |
T62167
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BI-10 是一种抗真菌化合物。BI-10 与氟康唑联合用药能够抑制菌丝的生长,积累 ROS,减少线粒体膜电位 (MMP),改变膜通透性。 |
T79413
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Antifungalagent 73 (compound A32)是一款用于治疗唑类耐药Candida感染的抗真菌药物。该化合物通过破坏真菌的细胞壁和细胞膜来发挥作用,并且针对病原真菌和氟康唑(Fluconazole)耐药菌株显示出有效的体内抗真菌活性。 |
T75178
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Antifungal agent 55 (compound A07) 是一种抗氟康唑 耐药菌株的强效抗真菌剂。Antifungal agent 55 比咪康唑 更有效。Antifungal agent 55 抑制白色念珠菌的 MIC 值为 0.25-1 μg/mL。 |
T70029
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Ibrexafungerp citrate is a triterpenoid antifungal. Similarly to echinocandins, it inhibits the synthesis of 1,3-β-d-glucan. However, it binds to a different site on the enzyme than echinocandins, resulting in limited cross-resistance. Ibrexafungerp exerts concentration-dependent fungicidal activity against Candida species and retains in vitro activity against most fluconazole-resistant strains. |