目录号 | 产品详情 | 靶点 | |
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T78361 | |||
Penicillin amidase(Penicillin acylase)是裂解青霉素酰基侧链的酶,用于生产6-氨基青霉烷酸,以及拆分外消旋混合物,合成肽和半合成β-内酰胺类抗生素。 | |||
T80361 | |||
SpHistin为一种抗菌肽(AMP)。该化合物能够结合LPS并增加细菌膜的透化性。SpHistin与利福平与阿奇霉素结合时,能够促进这些抗生素的细胞内摄取,从而提高对铜绿假单胞菌的杀菌效果。 | |||
T74828 | |||
Efflux pump-IN-3为一种AcrB外排泵抑制剂,具有增强抗生素效力的特性。该化合物能阻断尼罗红(AcrB已知的一种底物)的外排,而不会破坏细菌的外膜,并且在线虫模型中未展现出毒性。 | |||
T36475 | |||
TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared with tunicamycin. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactamsJ. Antibiot. (Tokyo)70(11)1070-1077(2017) | |||
T37283 | |||
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+. | |||
T74829 | |||
Efflux pump-IN-4是一种针对AcrB外排泵的抑制剂,能够增强抗生素效果。该化合物通过抑制尼罗红(AcrB的已知底物)的外排来发挥作用,同时不破坏细菌外膜,且在线虫模型中未显示出毒性。 | |||
T74827 | |||
Efflux pump-IN-2 是一种 AcrB 外排泵抑制剂,能够增强抗生素的作用。Efflux pump-IN-2 抑制尼罗红 (AcrB 的一种已知底物) 外排。Efflux pump-IN-2 不破坏细菌外膜,也不会在线虫模型中显示毒性。 | |||
T76126 | |||
Dextranase,即葡聚糖水解酶,常用于生化研究。Dextranase 可以催化葡聚糖中 α-(1,6)-糖苷键水解,具有广泛的应用,如食品加工、糖改性、活性分子制备以及在医学上用于可心内膜炎抗生素活性的增强剂等。 | |||
T75516 | |||
Seconeolitsine,一种抗生素,是一种靶向拓扑异构酶 I(TopA)的抑制剂。Seconeolitsine 也是一种新的抗菌剂,可以抑制 S. pneumoniae 的生长。Seconeolitsine 具有抑制 TopA 的活性,其 b>IC50值为 17 μM。Seconeolitsine 可用于对其他抗生素耐药的肺炎链球菌感染的研究。 | |||
T74917 | |||
KPC-2-IN-1,硼酸衍生物,是一种有效的 KPC-2抑制剂,其 Ki 值为 0.032 μM。KPC-2-IN-1 能增强 cefotaxime 在表达 KPC-2的大肠杆菌中的活性。KPC-2-IN-1 对人类 HEK-293 细胞显示良好的耐受性,可用于大肠杆菌耐β-lactam 类抗生素的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P52699.
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TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | P. pastoris (Yeast) | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPY-01812 | Enoyl-ACP Reductase Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI subfamily. Microorganisms produce many kinds of antibiotics which function in an antagonistic capacity in nature where they have much competition. Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FABI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. The antibiotic diazaborine interferes with the activity by binding to the protein. FABI is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Various compounds have been reported as inhibitors of bacterial FabI-inhibitory compounds.
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