PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T17415	Amino-PEG16-acid	Amino-PEG16-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16453	PEG2-bis(phosphonic acid diethyl ester)	PEG2-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative commonly employed as a linker in proteolysis-targeting chimeras (PROTACs) synthesis[1].
T18509	Oleoyl-Gly-Lys-N-(m-PEG11)	Oleoyl-Gly-Lys-N-(m-PEG11) is a cleavable 11 unit PEG linker utilized for the synthesis of antibody-drug conjugates (ADCs)[1].
T14438	Azido-PEG4-alcohol	Azido-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18022	HS-PEG24-CH2CH2COOH	HS-PEG24-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14403	Azido-PEG1-Boc	Azido-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15334	Fmoc-PEG6-NHS ester	Fmoc-PEG6-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17650	Boc-N-Amido-PEG5-Ms	Boc-N-Amido-PEG5-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15072	DBCO-PEG4-Maleimide	DBCO-PEG4-Maleimide is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17769	DBCO-NHCO-PEG3-Fmoc	DBCO-NHCO-PEG3-Fmoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17747	DBCO-C3-PEG4-NH-Boc	DBCO-C3-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18348	Methyltetrazine-PEG4-acid	Methyltetrazine-PEG4-acid is a PEG-based linker utilized in the synthesis of PROTACs[1].
T15764	Lipoamido-PEG4-acid	Lipoamido-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15901	m-PEG5-succinimidyl carbonate	m-PEG5-succinimidyl carbonate is a non-cleavable PEG linker with 5 units, utilized in the synthesis of antibody-drug conjugates (ADCs).
T17597	Biotin-PEG9-CH2CH2COOH	Biotin-PEG9-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18192	m-PEG36-azide	m-PEG36-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18577	Propargyl-PEG25-acid	Propargyl-PEG25-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17811	DBCO-SS-aldehyde	DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs).
T18701	SPDB-DM4	SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.
T18489	NH2-O-C5-COOH hydrobromide	NH2-O-C5-COOH (hydrobromide) is an alkyl chain-derived PROteolysis TArgeting Chimera (PROTAC) linker employed for PROTAC synthesis [1].

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PROTAC Linker