PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18510	OPSS-PEG36-acid	OPSS-PEG36-acid is a 36-unit PEG linker amenable to cleavage, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17744	DBCO-C2-PEG4-amine	DBCO-C2-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17421	Amino-PEG24-alcohol	Amino-PEG24-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14053	5-Maleimidovaleric acid	5-Maleimidovaleric acid, a cleavable linker for antibody-drug conjugates (ADCs) synthesis, is employed as an ADC linker[1].
T18021	HS-PEG11-CH2CH2N3	HS-PEG11-CH2CH2N3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15512	Hydroxy-PEG1-(CH2)2-Boc	Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].
T15866	m-PEG3-Tos	m-PEG3-Tos is a PEG-based PROTAC linker used in the synthesis of Silymarin [1].
T17750	DBCO-mPEG (MW 20kDa)	DBCO-mPEG (MW 20kDa) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15999	Mal-PEG6-acid	Mal-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18460	N-PEG3-N'-(azide-PEG3)-Cy5	N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a polyethylene glycol (PEG) derivative, commonly known as a PROTAC linker. This compound plays a crucial role in the synthesis of proteolysis targeting chimeras (PROTACs)[1]
T16243	N-(PEG2-Boc)-N-bis(PEG2-propargyl)	N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based PROTAC linker employed for the synthesis of PROTACs[1].
T13986	1,1,1-Trifluoroethyl-PEG4-amine	111-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker suitable for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T18082	m-PEG-azide (MW 10000)	m-PEG-azide (MW 10000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17829	Diketone-PEG4-PFP ester	Diketone-PEG4-PFP ester is a polyethylene glycol (PEG) derivative employed as a PROTAC linker in the fabrication of proteolysis-targeting chimeras (PROTACs)[1].
T18225	m-PEG9-C4-SH	m-PEG9-C4-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15889	m-PEG5-azide	m-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14167	Ald-Ph-PEG4-Boc	Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17509	Azido-PEG35-amine	Azido-PEG35-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17524	Azidoethyl-SS-propionic acid	Azidoethyl-SS-propionic acid is an ADC linker, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It possesses cleavable properties, allowing for the controlled release of drug payloads.
T18266	Mal-PEG-Succinimidyl Valerate (MW 20000)	Mal-PEG-Succinimidyl Valerate (MW 20000) is a polyethylene glycol (PEG)-based linker with a molecular weight of 20000. It serves as an essential component in the synthesis of PROTACs, which are proteolysis targeting chimeras.

注册成功

PROTAC Linker