PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18298	Mal-PEG8-alcohol	Mal-PEG8-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14461	Azido-PEG5-CH2CO2H	Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T16970	t-Boc-aminooxy-PEG6-propargyl	t-Boc-aminooxy-PEG6-propargyl is a PEG-based PROTAC linker utilized for PROTAC synthesis[1].
T18045	Hydroxy-PEG7-Boc	Hydroxy-PEG7-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16617	Propargyl-PEG4-beta-D-glucose	Propargyl-PEG4-beta-D-glucose is a polyethylene glycol (PEG) derivatized PROTAC linker employed in the preparation of PROteolysis TArgeting Chimeras (PROTACs)[1].
T16306	NH-bis(PEG4-Boc)	NH-bis(PEG4-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15882	m-PEG4-O-NHS ester	m-PEG4-O-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18384	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1].
T17745	DBCO-C2-PEG4-NH-Boc	DBCO-C2-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15854	m-PEG3-Boc	m-PEG3-Boc is a PROTAC linker derived from PEG and alkyl/ether, utilized in the synthesis of PROTACs[1].
T17736	Cy5-PEG5-amine hydrochloride	Cy5-PEG5-amine (hydrochloride) is a PEG-derived PROTAC linker employed for PROTAC synthesis[1].
T17601	Bis(m-PEG4)-N-OH	Bis(m-PEG4)-N-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18715	SPDP-PEG7-acid	SPDP-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18168	m-PEG24-Br	m-PEG24-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17849	DSPE-PEG-Amine (MW 5000)	DSPE-PEG-Amine (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker. It serves as an essential PROTAC linker component in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].
T15229	endo-BCN-PEG4-PFP ester	Endo-BCN-PEG4-PFP ester is a polyethylene glycol (PEG) derivative, specifically designed as a linker for proteolysis-targeting chimeras (PROTACs) [1].
T17740	Cyclooctyne-O-PFP ester	Cyclooctyne-O-PFP ester is utilized as an ADC cytotoxin to link antibodies and linkers [1].
T18732	sulfo-SPDB	sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
T17657	Boc-NH-PEG-amine (MW 3400)	Boc-NH-PEG-amine (MW 3400) serves as a PEG-based PROTAC linker and finds application in PROTAC synthesis[1].
T17386	Alkyne-PEG4-SS-PEG4-alkyne	Alkyne-PEG4-SS-PEG4-alkyne is an eight-unit polyethylene glycol (PEG) linker, designed for antibody-drug conjugates (ADCs) synthesis, that can be cleaved. This linker serves as a connection between the antibody and the drug, allowing for controlled release upon specific conditions [1].

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PROTAC Linker