PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16467	Pentaethylene glycol monomethyl ether	Pentaethylene glycol monomethyl ether (PEG-MME) is a PEG-based PROTAC linker, which is employed for the synthesis of PROTACs[1].
T16308	NH-bis-PEG4	NH-bis-PEG4 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16196	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a polyethylene glycol (PEG)-based linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs).
T14952	Chloroacetamido-PEG4-C2-Boc	Chloroacetamido-PEG4-C2-Boc is a PEG-based PROTAC linker that incorporates alkyl and ether functionalities. This compound is utilized in synthesizing PROTACs, offering a versatile platform for targeted protein degradation.
T18163	m-PEG23-alcohol	m-PEG23-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18464	N-(Tos-PEG4)-N-bis(PEG4-Boc)	N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].
T17596	Biotin-PEG8-NHS ester	Biotin-PEG8-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18028	HS-PEG7-CH2CH2N3	HS-PEG7-CH2CH2N3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18205	m-PEG48-Mal	m-PEG48-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14183	Alkyne-PEG4-maleimide	Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14000	[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid	The compound [10-(diethoxy-phosphoryl)-decyl]-phosphonic acid is a suitable alkyl chain-based PROTAC linker for the synthesis of PROTACs [1].
T17678	Boc-NH-PEG36-CH2CH2COOH	Boc-NH-PEG36-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker employed for the synthesis of PROTACs[1].
T16059	Methyltetrazine-PEG5-alkyne	Methyltetrazine-PEG5-alkyne, a PEG-based PROTAC linker, is utilized in synthesizing PROTACs[1].
T14827	Bromoacetamido-PEG8-acid	Bromoacetamido-PEG8-acid is a PEG-derived PROTAC linker suitable for synthesizing PROTACs[1].
T18278	Mal-PEG2-VCP-Eribulin	Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
T14725	Boc-Gly-amido-C-PEG3-C3-amine	Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker employed in PROTAC synthesis[1].
T16968	t-Boc-Aminooxy-PEG2-azide	t-Boc-Aminooxy-PEG2-azide is a polyethylene glycol (PEG) derived linker compound employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T18015	HO-PEG4-benzyl ester	HO-PEG4-benzyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17779	DBCO-PEG1-NHS ester	DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14629	Bis-PEG10-acid	Bis-PEG10-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker