PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16246	N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester	N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].
T16296	NH-bis(C2-PEG2-NH-Boc)	NH-bis(C2-PEG2-NH-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17332	3,4-Dibromo-Mal-PEG8-acid	The compound 3,4-Dibromo-Mal-PEG8-acid is a PEG-based PROTAC linker employed for PROTAC synthesis[1].
T18074	Lipoamido-PEG24-acid	Lipoamido-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16693	Pyrene-PEG5-alcohol	Pyrene-PEG5-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14656	Bis-propargyl-PEG3	Bis-propargyl-PEG3 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs. It is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (ZnDPA) complexes[1] [2].
T18235	Mal-amido-PEG10-C2-NHS ester	Mal-amido-PEG10-C2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker that consists of a maleimide group and an N-hydroxysuccinimide (NHS) ester. The NHS ester enables efficient labeling of primary amines (-NH2) in proteins, amine-modified oligonucleotides, and other amine-containing molecules[1][2].
T18179	m-PEG3-Mal	m-PEG3-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14433	Azido-PEG3-phosphonic acid ethyl ester	Azido-PEG3-phosphonic acid ethyl ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].
T18120	m-PEG10-CH2COOH	m-PEG10-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17365	Ala-Ala-Asn-PAB	Ala-Ala-Asn-PAB is a cleavable peptide linker used in antibody-drug conjugates (ADCs)[1].
T15950	Mal-amido-PEG2-C2-acid	Mal-amido-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18431	N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5	N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a polyethylene glycol (PEG) derived linker compound employed in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17410	Amino-PEG12-CH2COOH	Amino-PEG12-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14761	Boc-PEG4-phosphonic acid ethyl ester	Boc-PEG4-phosphonic acid ethyl ester is a polyethylene glycol (PEG) derived linker compound employed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].
T13988	1,1,1-Trifluoroethyl-PEG4-azide	111-Trifluoroethyl-PEG4-azide is a polyethylene glycol (PEG) derivative containing a trifluoroethyl moiety and an azide functional group. It serves as a PROTAC linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17320	1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane	1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a polyethylene glycol (PEG)-based linker compound suitable for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17458	Azide-PEG-amine (MW 3500)	Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) derived linker compound, specifically designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].
T18290	Mal-PEG4-VA	Mal-PEG4-VA, a noncleavable ADC linker featuring a Maleimide group, is utilized in the synthesis of antibody-drug conjugates.
T17598	Biotin-PEG9-NHS Ester	Biotin-PEG9-NHS Ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker