PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T14633	Bis-PEG2-PFP ester	Bis-PEG2-PFP ester is a non-cleavable 2-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs) [1]. Additionally, Bis-PEG2-PFP ester serves as a PEG-based linker for the synthesis of proteolysis targeting chimeras (PROTACs) [2].
T17804	DBCO-PEG5-DBCO	DBCO-PEG5-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15148	DNP-NH-PEG2-C2-acid	DNP-NH-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17370	Ald-Ph-amido-PEG24-acid	Ald-Ph-amido-PEG24-acid is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T16167	N-(4-Carboxycyclohexylmethyl)maleimide	N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs[1].
T17599	Bis-Bromoacetamido-PEG11	Bis-Bromoacetamido-PEG11 is a polyethylene glycol (PEG) derived linker compound, specifically designed for the synthesis of PROTACs[1].
T14535	Benzyl-PEG2-CH2-Boc	Benzyl-PEG2-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17961	Fmoc-N-PEG24-acid	Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18210	m-PEG5-triethoxysilane	m-PEG5-triethoxysilane is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15859	m-PEG3-NHS ester	m-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18832	Thiol-PEG-CH2COOH (MW 2000)	Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].
T17558	Biotin-PEG11-oxyamine	Biotin-PEG11-oxyamine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18821	Thalidomide-O-amido-PEG4-azide	Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].
T18581	Propargyl-peg3-sulfone-peg3-propargyl	Propargyl-PEG3-sulfone-PEG3-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T15965	Mal-amido-PEG9-amine	Mal-amido-PEG9-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16228	N-Mal-N-bis(PEG2-amine)	N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker compound commonly employed in the construction of PROTACs, or proteolysis-targeting chimeras[1].
T18700	SPB	SPB is a potent anti-inflammatory drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Xanthotoxol connected through the ADC linker.
T16229	N-Mal-N-bis(PEG2-C2-Boc)	N-Mal-N-bis(PEG2-C2-Boc) is a polyethylene glycol (PEG)-based linker for proteolysis targeting chimeras (PROTACs)[1].
T17632	Bis-propargyl-O-PEG17	Bis-propargyl-O-PEG17 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18326	MC-Val-Cit-PAB-MMAF	MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.

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PROTAC Linker