×
{{login.error}}
{{login.verifyresult}}
×
6~16个字符、区分大小写、必须包含字母和数字
6~16个字符、区分大小写、必须包含字母和数字
密码已经重置成功,快去使用新密码吧!
登录账号
密码已经重置成功,快去使用新密码吧! 登录账号
×

注册成功

确认

Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号 产品名称
T17883 Pomalidomide-PEG3-C2-NH2 Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 3 单元 PEG 的linker。
T17582 DADPS Biotin Azide DADPS Biotin Azide (Biotin-PEG4-amino-t-Bu-DADPS-C6-azide) 是一种属于 PEG 类的 PROTAC linker,可用于合成 PROTAC 分子。
T17015L (S)-TCO-PEG4-acid (S)-TCO-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17853 DSPE-PEG-Maleimide (MW 5000) DSPE-PEG-Maleimide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16603 Propargyl-PEG2-OH Propargyl-PEG2-OH is a polyethylene glycol (PEG)-based PROTAC linker, specifically designed for efficient synthesis of Thalidomide-O-PEG2-propargyl.
T17670 Boc-NH-PEG15-azide Boc-NH-PEG15-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17718 Cbz-NH-PEG10-CH2COOH Cbz-NH-PEG10-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18325 MC-Val-Cit-PAB-Indibulin MC-Val-Cit-PAB-Indibulin is an antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), featuring the orally active tubulin assembly inhibitor, Indibulin, connected through the MC-Val-Cit-PAB ADC linker. This compound exhibits potent antitumor activity.
T14182 Alkyne-ethyl-PEG1-Boc Alkyne-ethyl-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15078 DBCO-Sulfo-NHS ester sodium DBCO-Sulfo-NHS ester sodium is a cleavable linker predominantly employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18349 Methyltetrazine-PEG4-NH-Boc Methyltetrazine-PEG4-NH-Boc is a PEGylation-based linker employed for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
T18623 Boc-NH-PEG2-C2-amido-C4-acid Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T18164 m-PEG24-NHS ester m-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14771 Br-PEG4-C2-Boc Br-PEG4-C2-Boc is a cleavable 4-unit PEG ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T15297 Fluorescein-thiourea-PEG2-azide Fluorescein-thiourea-PEG2-azide is a PEG-derived linker commonly applied for the synthesis of PROTACs[1].
T15873 m-PEG4-C6-phosphonic acid ethyl ester m-PEG4-C6-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker compound utilized for synthesizing proteolysis-targeting chimeras (PROTACs)[1].
T17888 cIAP1 Ligand-Linker Conjugates 6 hydrochloride cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1].
T16637 Propargyl-PEG6-NHS ester Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T14605 Biotin-PEG5-NH-Boc Biotin-PEG5-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18280 Mal-PEG24-acid Mal-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
联系我们
400-820-0310
service@tsbiochem.com

上海市静安区江场三路238号8楼