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PROTAC-linker Conjugate for PAC

产品编号 产品名称
T18514 PAC PAC, derived from the compound LP2 described in patent WO2017201449A1, is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC alone.
T18603 PROTAC BRD4 degrader for PAC-1 PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.
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