表型筛选靶点鉴定库

Target-Focused Phenotypic Screening Library
产品编号 L9500
  库化合物信息   Excel SDF

TargetMol表型筛选靶点鉴定库是专为表型筛选的科研工作者提供的,众所周知,表型筛选中的体外筛选,通常以细胞作为筛选工具,优点是对于靶点还不明晰,或靶点与疾病之间的关系还不明确时的药物开发,具有非常好的效果,常用于First-in-class药物的研发。而活性化合物的发现与靶标的鉴定两者间实现无缝对接,是学术界和产业界关注的焦点和难点。

选用靶点明确的已知活性化合物进行表型筛选,可以缩小后期靶点确认的范围,是一种较好的基于表型进行靶点鉴定的方式。该库针对表型筛选后难以确定靶点作用机制的痛点,精选了对600多个药物靶点有明确活性的1832个小分子组成了该化合物库。每个靶点采取2-4个结构差异较大的化合物,以正交矩阵原理提高靶点鉴定的成功率,把表型筛选和靶点作用机制判断融为一体,是表型筛选的有力工具。

表型筛选靶点鉴定库
规格 价格/RMB
100 μL * 10 mM (in DMSO) 151700.00
250 μL * 10 mM (in DMSO) 231800.00
1 mg 231800.00
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产品描述

  • 1832种靶点明确的已知活性化合物,适合表型筛选;
  • 覆盖600多个药物靶点,多样性好,覆盖度广,使用方便;
  • 每个靶点对应2-4个结构差异较大的化合物,提高靶点确认的成功率;
  • 详细的说明书,化合物结构、靶点信息、活性描述,方便科学家对结果进行分析;
  • NMR、HPLC/LCMS多重严苛出厂检测,保证产品结构准确,纯度高,保障实验顺利进行。

化合物库定制

我们的化合物库可以灵活定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L9500)

化合物库组成

AChR (56)
5-HT Receptor (44)
Adrenergic Receptor (44)
VEGFR (36)
DNA/RNA Synthesis (35)
PI3K (29)
P450 (28)
Epigenetic Reader Domain (27)
FGFR (25)
PDE (25)
Histone Methyltransferase (24)
TRP/TRPV Channel (23)
Bcr-Abl (22)
GluR (21)
CDK (20)
Microtubule Associated (20)
PDGFR (19)
Raf (19)
HDAC (19)
EGFR (19)
Src (19)
GPR (18)
GABA Receptor (18)
RAAS (17)
HIV Protease (17)
PPAR (16)
c-Met/HGFR (16)
Topoisomerase (16)
c-Kit (15)
Dopamine Receptor (15)
COX (15)
Potassium Channel (15)
Opioid Receptor (15)
Histamine Receptor (15)
JAK (15)
MAO (15)
HCV Protease (14)
p38 MAPK (14)
DNA Alkylation (14)
FLT (14)
Estrogen/progestogen Receptor (14)
TNF (14)
Vitamin (14)
ERK (13)
BCL (13)
mTOR (13)
Histone Demethylase (12)
Gamma-secretase (12)
Glucokinase (12)
Cannabinoid Receptor (11)
Carbonic Anhydrase (11)
IL Receptor (11)
P2 Receptor (11)
PKC (11)
Retinoid Receptor (11)
STAT (11)
Wnt/beta-catenin (10)
S1P Receptor (10)
Sirtuin (10)
Sodium Channel (10)
NF-κB (10)
HSP (10)
HIF (10)
NMDAR (10)
Aurora Kinase (10)
Autophagy (10)
CXCR (10)
CaMK (9)
Beta Amyloid (9)
Chk (9)
Adenosine Receptor (9)
ATPase (9)
IκB/IKK (9)
Serine Protease (9)
ribosome (9)
TGF-beta/Smad (9)
Trk receptor (9)
Sigma receptor (8)
ROR (8)
NOS (8)
PARP (8)
JNK (8)
IDO (8)
MEK (8)
MMP (8)
ALK (8)
Akt (8)
Caspase (8)
Calcium Channel (8)
Dehydrogenase (8)
DNA-PK (8)
DUB (8)
GSK-3 (8)
Hedgehog/Smoothened (7)
BTK (7)
ATM/ATR (7)
Mdm2 (7)
NADPH (7)
HMG-CoA Reductase (7)
S6 Kinase (7)
Serine/threonin kinase (7)
Prostaglandin Receptor (7)
Reductase (7)
Thyroid hormone receptor(THR) (7)
Syk (7)
TLR (6)
SGLT (6)
Phospholipase (6)
Lipase (6)
CFTR (6)
Chloride channel (5)
CCR (5)
c-Fms (5)
Casein Kinase (5)
Aromatase (5)
AhR (5)
GR (5)
Glucocorticoid Receptor (5)
Endothelin Receptor (5)
Cysteine Protease (5)
Lipoxygenase (5)
Monocarboxylate transporter (5)
MRP (5)
NOD (5)
PKM (5)
OX Receptor (5)
ROCK (5)
Reverse Transcriptase (5)
Rho (5)
Proteasome (5)
Transferase (5)
Tyrosine Kinases (5)
Trace amine-associated receptor 1 (4)
Transcriptional regulator ERG (4)
Thyroid stimulating hormone receptor (4)
Tie-2 (4)
Thioredoxin glutathione reductase (4)
Thioredoxin reductase 1, cytoplasmic (4)
Thrombin (4)
Thyroid hormone receptor beta-1 (4)
TAM Receptor (4)
TAR DNA-binding protein 43 (4)
Streptokinase A (4)
Tyrosinase (4)
Ras-related protein Rab-9A (4)
Prelamin-A/C (4)
PKA (4)
ROS (4)
Short transient receptor potential channel 4 (4)
Serotonin 2c (5-HT2c) receptor (4)
Neuropeptide S receptor (4)
Nuclear factor erythroid 2-related factor 2 (4)
Nuclear receptor ROR-gamma (4)
Niemann-Pick C1 protein (4)
PD-1/PD-L1 (4)
p53 (4)
p97 (4)
PLK (4)
Phosphorylase (4)
Parasite (4)
P-glycoprotein 1 (4)
P-gp (4)
Phosphatase (4)
Nonstructural protein 1 (4)
Norepinephrine (4)
Mothers against decapentaplegic homolog 3 (4)
Monoamine oxidase B (4)
Metabotropic glutamate receptor 5 (4)
microRNA 21 (4)
LRRK2 (4)
Luciferin 4-monooxygenase (4)
Lysosomal alpha-glucosidase (4)
Lipid (4)
Kinesin (4)
Large T antigen (4)
Lethal(3)malignant brain tumor-like protein 1 (4)
Inositol monophosphatase 1 (4)
Histone Acetyltransferase (4)
IGF-1R (4)
Huntingtin (4)
Cruzipain (4)
CSF-1R (4)
DHFR (4)
DNA dC->dU-editing enzyme APOBEC-3F (4)
DNA Methyltransferase (4)
DNA polymerase eta (4)
DNA polymerase iota (4)
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (4)
DPP-4 (4)
GPCR19 (4)
Glutaminase kidney isoform, mitochondrial (4)
Glycoprotein hormones alpha chain (4)
Guanine nucleotide-binding protein G(s), subunit alpha (4)
HBV (4)
Geminin (4)
Glucagon-like peptide 1 receptor (4)
FXR (4)
FAAH (4)
Factor Xa (4)
FK506 binding protein 12 (4)
FAK (4)
Aldehyde dehydrogenase 1A1 (4)
4'-phosphopantetheinyl transferase ffp (4)
ABC (4)
ATPase family AAA domain-containing protein 5 (4)
ATP-dependent Clp protease proteolytic subunit (4)
ATP-dependent DNA helicase Q1 (4)
ATP-dependent molecular chaperone HSP82 (4)
Alpha-galactosidase A (4)
Alpha-synuclein (4)
AMPK (4)
Androgen Receptor (4)
Anthrax lethal factor (4)
CaSR (4)
Beta-glucocerebrosidase (4)
Beta-lactamase AmpC (4)
BMI-1 (4)
Breast cancer type 1 susceptibility protein (4)
Bromodomain adjacent to zinc finger domain protein 2B (3)
Beta-2 adrenergic receptor (3)
Cell wall (3)
CETP (3)
c-Myc (3)
Antifungal (3)
Arachidonate 15-lipoxygenase, type II (3)
Ataxin (3)
ACAT (3)
15-hydroxyprostaglandin dehydrogenase [NAD+] (3)
Fatty Acid Synthase (3)
FAD-linked sulfhydryl oxidase ALR (3)
G protein-coupled receptor 44 (3)
HER (3)
GNRH Receptor (3)
E1/E2/E3 Enzyme (3)
DNA gyrase (3)
Ephrin Receptor (3)
Epoxide hydratase (3)
C-X-C chemokine receptor type 7 (3)
c-RET (3)
Cytochrome P450 1A2 (3)
HIF/HIF Prolyl-Hydroxylase (3)
Isocitrate dehydrogenase [NADP] cytoplasmic (3)
LIM Kinase (3)
LDL (3)
Lipoxin A4 receptor (3)
LTR (3)
Microtubule-associated protein tau (3)
MNK (3)
Na-K-Cl cotransporter (3)
Neurokinin 3 receptor (3)
Neurokinin receptor (3)
PDK (3)
Porcupine (3)
Protease-activated Receptor (3)
Proton pump (3)
Survival motor neuron protein (3)
Telomerase (3)
transporter (3)
Tumor susceptibility gene 101 protein (3)
Tyrosyl-DNA phosphodiesterase 1 (3)
Voltage-gated T-type calcium channel alpha-1G subunit (3)
Voltage-gated T-type calcium channel alpha-1H subunit (2)
Wee1 (2)
UGT (2)
Vanilloid receptor (2)
Vasopressin Receptor (2)
Testis-specific androgen-binding protein (2)
TGF-beta receptor type II (2)
Survivin (2)
PTEN (2)
Prostaglandin E synthase (2)
Pim (2)
Runt-related transcription factor 1/Core-binding factor subunit beta (2)
PGE Synthase (2)
PERK (2)
Phosphodiesterase 5A (2)
PAFR (2)
PAI-1 (2)
Paired box protein Pax-8 (2)
MTH1 (2)
NAMPT (2)
Monoamine Transporter (2)
MLK (2)
Melatonin Receptor (2)
MAPK (2)
Liver X Receptor (2)
Integrin (2)
Interleukin Related (2)
Hydroxylase (2)
HSV (2)
Influenza Virus (2)
Cytochrome P450 2C9 (2)
Cytochrome P450 19A1 (2)
DNA dC->dU-editing enzyme APOBEC-3G (2)
Estrogen receptor alpha (2)
Endogenous Metabolite (2)
DprE1 (2)
Dopamine D2 receptor (2)
GlyT (2)
Formyl peptide receptor 1 (2)
GluCls (2)
Gap Junction Protein (2)
advanced glycation end products (2)
Aldo-keto-reductase family 1 member C3 (2)
Acetyl-CoA Carboxylase (2)
ACK (2)
Acyltransferase (2)
Adenosine A1 receptor (2)
Antifection (2)
C-C chemokine receptor type 5 (2)
Carboxypeptidase(CPG2) (2)
Butyrylcholinesterase (2)
cAMP (2)
BACE (2)
BCRP (1)
CAT (1)
Cholesteryl ester transfer protein (1)
Arginase (1)
Annexin A (1)
ATP Citrate Lyase (1)
Excitatory amino acid transporter 1 (1)
Ferroptosis (1)
Hck (1)
DNA Alkylator/Crosslinker (1)
Hippo pathway (1)
IP3 Receptor  (1)
Keap1-Nrf (1)
Menin/Histone-lysine N-methyltransferase MLL (1)
lysosomal autophagy (1)
MPO (1)
MT Receptor (1)
Peroxisome proliferator-activated receptor gamma (1)
Serotonin Transporter (1)
SGK (1)
Pyruvate kinase isozymes M1/M2 (1)
Wnk (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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