首页Chromatin/EpigeneticEpigenetic Reader DomainPF-CBP1 hydrochloride
PF-CBP1 hydrochloride
编号 T3217     别名: PF-CBP1 HCl
CAS 2070014-93-4     分子式 C29H37ClN4O3     分子量 525.08
靶点: CREBBP; p300/CBP;
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
纯度:95.87%
规格 库存 单价 数量
5 mg 上海现货 557.00
10 mg 上海现货 754.00
25 mg 上海现货 1763.00
50 mg 上海现货 3312.00
100 mg 上海现货 5800.00
200 mg 上海现货 8100.00
1 mL * 10 mM (in DMSO) 上海现货 754.00
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生物活性

产品描述

PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.

靶点活性

CREBBP,

p300/CBP,

体外活性

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson's disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high[1].

体内活性

化学信息

分子量

525.08

分子式

C29H37ClN4O3

CAS

2070014-93-4

溶解度

DMSO: 100 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.904 ml 9.522 ml 19.045 ml
5 mM 0.381 ml 1.904 ml 3.809 ml
10 mM 0.19 ml 0.952 ml 1.904 ml
50 mM 0.038 ml 0.19 ml 0.381 ml
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