首页 Cell Cycle/Checkpoint CDK BSJ-03-123
BSJ-03-123
编号 T5395    
CAS T5395     分子式 C48H57N9O11     分子量 937.01
靶点: CDK6;
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
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规格 库存 单价 数量
1 mg 上海现货 998.00
5 mg 上海现货 2218.00
10 mg 上海现货 3106.00
50 mg 上海现货 6699.00
1 mL * 10 mM (in DMSO) 上海现货 2800.00
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生物活性

产品描述

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.

靶点活性

CDK6,

体外活性

BSJ-03-123 induced rapid, dose-dependent ternary complex formation with CDK6 and CRBN, but not with CDK4 and CRBN. Ternary complex formation was prevented by blocking binding sites on CDK6 or CRBN via pretreatment with palbo or lenalidomide.

体内活性

细胞实验

4x10^6 MV4-11 CRBN-/- cells were treated for 3 h with 20 μM palbociclib, BSJ-03-123 or vehicle. 1x10^6 cells were spun down at 500 x g for 5 min, and the supernatant removed. Pellets were incubated at 46, 49, 52 or 55°C for 3 min followed by 3 min incubation at room temperature. 30 μl of lysis buffer (20 mM Tris-HCl pH 8.0, 120 mM NaCl, 0.5% NP-40, protease inhibitors) were added and cells lysed by 3 rounds of snap freezing and thawing. Denatured proteins were removed by 20 min centrifugation at 14.000 x g at 4°C and supernatants analyzed by Western Blotting.

化学信息

分子量

937.01

分子式

C48H57N9O11

CAS

T5395

溶解度

DMSO: 115 mg/mL (122.73 mM)

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.067 ml 5.336 ml 10.672 ml
5 mM 0.213 ml 1.067 ml 2.134 ml
10 mM 0.107 ml 0.534 ml 1.067 ml
50 mM 0.021 ml 0.107 ml 0.213 ml
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