TGF-β/Smad靶点化合物库

TGF-beta/Smad Compound Library

产品编号： L4100

转化生长因子-β（transforming growth factor-β,TGF-β)是属于一组新近发现的调节细胞生长和分化的 TGF-β超家族。在哺乳动物至少发现有 TGF-β1、TGF-β2、TGF-β3、TGF-β1β2四个亚型。许多细胞表面都有TGF-β受体，例如：成纤维细胞、淋巴细胞、造血细胞等。转化生长因子-β（TGF-β）信号通路在成熟有机体和发育中的胚胎中都参与了许多细胞过程，包括细胞生长、细胞分化、细胞凋亡、细胞动态平衡和免疫功能等。TGF-β与膜受体结合，受体再磷酸化R-SMAD（Smad2或Smad3），这些蛋白再与coSMAD (Smad4) 结合成R-SMAD/coSMAD 复合体作为转录因子在细胞核内聚集，参与靶基因表达的调控。

TargetMol 作为全球知名的化合物库供应商，积极关注科研动态，为您精选了185 个特异性好的TGF-β/Smad 靶点相关的小分子化合物，用于相关信号通路研究及药物的筛选，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

185个TGF-β/Smad靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

我们的化合物库可以灵活定制！了解更多

化合物库咨询

化合物库组成

PKC (77)

TGF-beta/Smad (59)

ROCK (44)

Apoptosis (22)

ALK (19)

Autophagy (18)

PKA (16)

ERK (8)

CDK (8)

Antibacterial (7)

Src (6)

Akt (6)

Serine/threonin kinase (5)

Endogenous Metabolite (5)

S6 Kinase (5)

Parasite (4)

VEGFR (4)

Calcium Channel (4)

PDGFR (4)

CaMK (4)

DNA/RNA Synthesis (4)

Casein Kinase (4)

SGK (4)

p38 MAPK (3)

Antifungal (3)

BCL (3)

EGFR (3)

Influenza Virus (3)

NF-κB (3)

AMPK (3)

HIV Protease (2)

Phosphatase (2)

GSK-3 (2)

Tyrosine Kinases (2)

Wnt/beta-catenin (2)

Rho (2)

Myosin (2)

LDL (2)

GRK (2)

IGF-1R (2)

COX (2)

MAPK (2)

5-HT Receptor (2)

MEK (2)

FGFR (2)

FLT (2)

Syk (2)

Sodium Channel (2)

Antibiotic (2)

MLK (2)

ATPase (1)

Proton pump (1)

NOS (1)

YAP (1)

PI3K (1)

c-Met/HGFR (1)

RAAS (1)

JNK (1)

Virus Protease (1)

Estrogen Receptor/ERR (1)

PARP (1)

Serine Protease (1)

Nucleoside Antimetabolite/Analog (1)

Caspase (1)

Topoisomerase (1)

RIP kinase (1)

UGT (1)

Bcr-Abl (1)

AAK1 (AP2 associated kinase 1) (1)

BTK (1)

Antifection (1)

Opioid Receptor (1)

Reactive Oxygen Species (1)

DNA Alkylation (1)

JAK (1)

HSV (1)

CCR (1)

Chk (1)

Aurora Kinase (1)

mTOR (1)

Antiviral (1)

LRRK2 (1)

Trk receptor (1)

PAI-1 (1)

STAT (1)

Ras (1)

TAM Receptor (1)

p53 (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

注册成功