成骨分子库 | 陶术生物

成骨分子库现货

Osteogenesis Compound Library

产品编号： L7900

人类的骨质是由成骨细胞进行骨质的合成和破骨细胞进行骨质的降解相协调统一的结果。成骨与破骨过程的平衡是维持正常骨质的关键。老年人的骨质分解代谢超过了合成代谢，导致了骨质疏松等病症。成骨细胞是骨形成的主要功能细胞，负责骨基质的合成、分泌和矿化。目前，随着研究的不断深入，在骨形成过程中，成骨细胞发展及其调控的分子机制也逐渐得以揭示。成骨细胞在骨形成过程中要经历成骨细胞增殖、细胞外基质成熟、细胞外基质矿化和成骨细胞凋亡四个阶段。很多因素可调节这几个阶段，从而调控骨形成。 TargetMol 作为全球知名的化合物库供应商，积极关注科研动态，通过检索近几年国内外成骨分化及成骨相关信号通路研究的文献，发现多条信号通路参与成骨细胞增殖与分化，其中，BMP-SMAD、Wnt/β-Catenin、Notch、Hedgehog、MAPK、FGF 信号通路在成骨分化过程中较为关键。多条信号通路间存在着相互作用，构成了一个复杂的调控网络。成骨分子库集合了320 种文献报道的成骨相关的生物活性分子，适合于成骨相关机理研究及药物筛选。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

320种成骨相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括BMP-SMAD、Wnt/β-Catenin、Notch、Hedgehog、MAPK、FGF等；
是研究成骨过程及相关疾病的有效工具，例如骨质疏松、骨肿瘤等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

p38 MAPK (72)

FGFR (71)

Wnt/beta-catenin (65)

Autophagy (61)

Apoptosis (59)

MAPK (35)

VEGFR (31)

ERK (27)

PDGFR (26)

Hedgehog/Smoothened (25)

Src (17)

JNK (16)

NF-κB (15)

c-Kit (13)

Smo (12)

FLT (11)

Endogenous Metabolite (10)

PARP (10)

Aurora Kinase (9)

CDK (9)

Akt (7)

Antibacterial (7)

Antifungal (7)

Casein Kinase (7)

Caspase (7)

EGFR (7)

JAK (7)

TGF-beta/Smad (7)

Bcr-Abl (6)

c-RET (6)

PERK (6)

Raf (6)

STAT (6)

ALK (5)

c-Fms (5)

COX (5)

IGF-1R (5)

MEK (5)

Parasite (5)

PKC (5)

Reactive Oxygen Species (5)

S6 Kinase (5)

ASK (4)

BCL (4)

c-Met/HGFR (4)

GSK-3 (4)

Porcupine (4)

TNF (4)

AMPK (3)

Antibiotic (3)

DNA/RNA Synthesis (3)

FAK (3)

Ferroptosis (3)

IL Receptor (3)

P450 (3)

Phosphatase (3)

PKA (3)

5-HT Receptor (2)

AChE (2)

Antioxidant (2)

Calcium Channel (2)

Carbonic Anhydrase (2)

Chk (2)

HER (2)

Influenza Virus (2)

IκB/IKK (2)

MMP (2)

NO Synthase (2)

Serine Protease (2)

Tie-2 (2)

Topoisomerase (2)

Trk receptor (2)

ABC (1)

AChR (1)

ACK (1)

Adenosine Receptor (1)

AhR (1)

Androgen Receptor (1)

Antifection (1)

Antiviral (1)

Arginase (1)

Aromatase (1)

Aryl Hydrocarbon Receptor (1)

ATPase (1)

Beta Amyloid (1)

CaMK (1)

CSF-1R (1)

DHFR (1)

Discoidin Domain Receptor (DDR) (1)

DNA (1)

DNA Alkylation (1)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (1)

Estrogen/progestogen Receptor (1)

GABA Receptor (1)

Glucokinase (1)

Guanylate cyclase (1)

HBV (1)

Hck (1)

Histamine Receptor (1)

HIV Protease (1)

HSV (1)

Kinesin (1)

Lipase (1)

Lipoxygenase (1)

MAGL (1)

MELK (1)

Microtubule Associated (1)

Mitophagy (1)

MNK (1)

mTOR (1)

NOD (1)

P-gp (1)

Phosphorylase (1)

PI3K (1)

PLK (1)

PPAR (1)

Ras (1)

Rho (1)

S1P Receptor (1)

SGK (1)

Sodium Channel (1)

Syk (1)

TAM Receptor (1)

TLR (1)

transporter (1)

TRP/TRPV Channel (1)

TSH Receptor (1)

Tyrosine Kinases (1)

Virus Protease (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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