高选择性抑制剂库

Highly Selective Inhibitor Library

产品编号： L2010

高选择性抑制剂能够高度选择性地影响目标分子或通路，而对其他非目标分子的影响相对较小。这种选择性是指药物在生物体内能够特异性地与目标分子相互作用，而对非目标分子产生较小或几乎没有影响。与非选择性抑制剂相比，高选择性抑制剂的优势在于其更精确地作用于目标靶点，从而降低了对非目标靶点的干扰，减少了可能的副作用和毒性。高选择性抑制剂在药物研发中的应用广泛，特别是在癌症治疗和其他复杂疾病的治疗方面，应用于药物开发中，可以更有效地干预病理过程，提高治疗的效果，并降低不良反应的发生率。

TargetMol 收集了575种高选择性抑制剂，绝大部分抑制剂相对于其他靶点的选择性至少高一百倍，是药物开发的有效工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

xunm种具有高选择性的抑制剂集合；
涵盖170种药物靶点；
部分抑制剂已得到FDA批准上市；
涵盖多种信号通路，如离子通道; NF-κB; PI3K/Akt/mTOR signaling; MAPK等
结构多样，生物活性强，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (95)

Autophagy (62)

EGFR (33)

PI3K (25)

Histone Methyltransferase (20)

Epigenetic Reader Domain (20)

CDK (19)

BTK (18)

mTOR (15)

c-Met/HGFR (14)

GSK-3 (14)

Proteasome (13)

Aurora Kinase (13)

FGFR (13)

DPP-4 (12)

Src (11)

Raf (11)

HDAC (11)

MEK (11)

JAK (10)

PDGFR (10)

Antibacterial (10)

FLT (10)

PARP (9)

VEGFR (9)

HIV Protease (8)

Chk (8)

COX (8)

SGLT (8)

Cysteine Protease (7)

TRP/TRPV Channel (7)

ERK (7)

PDE (7)

BCL (7)

PLK (7)

Antibiotic (7)

DNA-PK (6)

Histone Demethylase (6)

PPAR (6)

TGF-beta/Smad (6)

DNA/RNA Synthesis (6)

SARS-CoV (6)

Trk receptor (6)

IκB/IKK (6)

ATM/ATR (6)

HER (6)

p38 MAPK (5)

Dehydrogenase (5)

Ferroptosis (5)

Phosphatase (5)

Mitophagy (5)

Virus Protease (5)

Serine Protease (5)

PKC (5)

Adrenergic Receptor (5)

MMP (5)

Histone Acetyltransferase (5)

ALK (5)

c-Fms (5)

P450 (5)

c-Kit (5)

Ras (5)

Ligands for Target Protein for PROTAC (4)

PERK (4)

Lipase (4)

PKA (4)

Tyrosine Kinases (4)

Wnt/beta-catenin (4)

ROCK (4)

MAO (4)

CSF-1R (4)

RIP kinase (4)

FAAH (4)

DUB (4)

Akt (4)

Sirtuin (4)

Casein Kinase (4)

GPR (4)

PDK (4)

5-HT Receptor (4)

Potassium Channel (4)

AChR (4)

TAM Receptor (4)

HCV Protease (3)

RAAS (3)

JNK (3)

Factor Xa (3)

Serine/threonin kinase (3)

Caspase (3)

iGluR (3)

E1/E2/E3 Enzyme (3)

GluR (3)

IGF-1R (3)

MNK (3)

HSP (3)

Prostaglandin Receptor (3)

Influenza Virus (3)

STAT (3)

Syk (3)

S6 Kinase (3)

Thrombin (3)

Monoamine Oxidase (3)

Kinesin (3)

Proton pump (2)

NOS (2)

Dopamine Receptor (2)

Estrogen/progestogen Receptor (2)

LPL Receptor (2)

Adenosine Receptor (2)

DYRK (2)

NADPH (2)

Glutathione Peroxidase (2)

Tie-2 (2)

Estrogen Receptor/ERR (2)

Parasite (2)

Pim (2)

IDO (2)

Bcr-Abl (2)

GRK (2)

Phosphorylase (2)

Mitochondrial Metabolism (2)

Isocitrate Dehydrogenase (IDH) (2)

Integrase (2)

Reactive Oxygen Species (2)

HSV (2)

CXCR (2)

Endothelin Receptor (2)

KSP (2)

cAMP (2)

CaMK (2)

Indoleamine 2,3-Dioxygenase (IDO) (2)

MAPK (2)

LRRK2 (2)

transporter (2)

AMPK (2)

Hydroxylase (2)

Cannabinoid Receptor (2)

Neurokinin receptor (2)

NOD (2)

Sodium Channel (2)

NOD-like Receptor (NLR) (2)

Mdm2 (1)

ATPase (1)

Chloride channel (1)

Carbonic Anhydrase (1)

Transferase (1)

MALT (1)

Dynamin (1)

YAP (1)

Antifungal (1)

IFNAR (1)

Histamine Receptor (1)

Progesterone Receptor (1)

Galectin (1)

Rho (1)

NAMPT (1)

Glutaminase (1)

Calcium Channel (1)

Immunology/Inflammation related (1)

Glucocorticoid Receptor (1)

SIK (1)

Topoisomerase (1)

IRE1 (1)

MTH1 (1)

FABP (1)

NMDAR (1)

GlyT (1)

Monoamine Transporter (1)

ROS (1)

Opioid Receptor (1)

Neuropeptide Y Receptor (1)

Fatty Acid Synthase (1)

PAK (1)

CCR (1)

Vasopressin Receptor (1)

OX Receptor (1)

Epoxide Hydrolase (1)

ACK (1)

Lipoxygenase (1)

DNA (1)

Interleukin (1)

Telomerase (1)

Wee1 (1)

BCRP (1)

AChE (1)

P-gp (1)

Porcupine (1)

TLR (1)

CD73 (1)

Decarboxylase (1)

cGAS (1)

ASK (1)

Reverse Transcriptase (1)

LPA Receptor (1)

NF-κB (1)

Phospholipase (1)

GABA Receptor (1)

HIF (1)

c-RET (1)

SGK (1)

Complement System (1)

DAPK (1)

Platelet aggregation (1)

DNA Methyltransferase (1)

BMI-1 (1)

IRAK (1)

Sigma receptor (1)

Microtubule Associated (1)

Protease-activated Receptor (1)

FAK (1)

HIF/HIF Prolyl-Hydroxylase (1)

MLK (1)

PD-1/PD-L1 (1)

NO Synthase (1)

PKM (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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