内质网应激化合物库 | 陶术生物

内质网应激化合物库现货

Endoplasmic Reticulum Stress Compound Library

产品编号： L9700

内质网应激（Endoplasmic Reticulum stress）是细胞为应对内质网腔内错误折叠与未折叠蛋白聚集以及钙离子平衡紊乱等状况，而激活未折叠蛋白反应、内质网超负荷反应和 caspase-12 介导的凋亡通路等信号途径的反应过程。内质网应激既能诱导葡糖调节蛋白(glucose-regulated protein)GRP78、GRP94 等内质网分子伴侣表达而产生保护效应，亦能独立地诱导内源性细胞凋亡，并影响应激细胞的转归，如适应、损伤或凋亡。内质网应激是一种重要的防御机制，参与多种疾病进程，是一种泛在的病因机制。近年来的研究表明，癌症、炎症性疾病、代谢性疾病、骨质疏松症及神经退行性疾病等有内质网应激信号传递参与。 TargetMol 内质网应激化合物库收录了 193 个内质网应激相关的化合物，靶向 PERK、IRE1、ATF6、GRP78等内质网应激信号通路相关靶点，是研究内质网应激及相关疾病的良好工具。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

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产品描述

193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；
研究内质网应激及相关疾病的良好工具；
靶点包含PERK、IRE1、ATF6、GRP78等内质网应激信号通路相关靶点；
详细的说明书，化合物结构、靶点信息、活性描述等；
严格质检，保证产品结构准确，纯度高，保障实验顺利进行。

化合物库定制

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化合物库组成

Apoptosis (63)

Autophagy (51)

HSP (34)

PERK (18)

JNK (15)

IRE1 (15)

Endogenous Metabolite (13)

Mitophagy (9)

AMPK (8)

COX (7)

Antibacterial (7)

NF-κB (7)

Antibiotic (7)

Reactive Oxygen Species (6)

GPR (6)

P450 (6)

HIV Protease (5)

ERK (5)

p97 (5)

Phosphatase (4)

PPAR (4)

Akt (4)

MEK (4)

Ferroptosis (3)

Caspase (3)

Calcium Channel (3)

Mitochondrial Metabolism (3)

MMP (3)

DNA/RNA Synthesis (3)

Prostaglandin Receptor (3)

HDAC (3)

5-HT Receptor (3)

GABA Receptor (3)

c-Kit (3)

Proteasome (2)

Mdm2 (2)

Chloride channel (2)

Src (2)

Estrogen/progestogen Receptor (2)

Antifungal (2)

PI3K (2)

Antioxidant (2)

Histamine Receptor (2)

Glutathione Peroxidase (2)

VEGFR (2)

Gamma-secretase (2)

CDK (2)

PDGFR (2)

Aurora Kinase (2)

Lipoxygenase (2)

DUB (2)

mTOR (2)

TGF-beta/Smad (2)

MAPK (2)

AChE (2)

SARS-CoV (2)

Sirtuin (2)

ASK (2)

Casein Kinase (2)

Phospholipase (2)

HIF (2)

FLT (2)

Sodium Channel (2)

ATPase (1)

Transferase (1)

Monocarboxylate transporter (1)

ROR (1)

Dopamine Receptor (1)

HCV Protease (1)

Integrin (1)

p38 MAPK (1)

Dehydrogenase (1)

NADPH (1)

Histone Demethylase (1)

CETP (1)

Melatonin Receptor (1)

MRP (1)

HBV (1)

Tyrosine Kinases (1)

Parasite (1)

Cysteine Protease (1)

Nucleoside Antimetabolite/Analog (1)

FXR (1)

TRP/TRPV Channel (1)

RANKL/RANK (1)

Glucocorticoid Receptor (1)

Topoisomerase (1)

E1/E2/E3 Enzyme (1)

UGT (1)

PDE (1)

MTH1 (1)

Raf (1)

Hexokinase (1)

PROTAC Linker (1)

Stearoyl-CoA Desaturase (SCD) (1)

HSV (1)

PTEN (1)

Epigenetic Reader Domain (1)

CaMK (1)

Androgen Receptor (1)

Interleukin (1)

ATP Citrate Lyase (1)

PGE Synthase (1)

P-gp (1)

Trk receptor (1)

Nrf2 (1)

Influenza Virus (1)

IκB/IKK (1)

Beta Amyloid (1)

GPX (1)

PDK (1)

Adenosine deaminase (1)

TNF (1)

Potassium Channel (1)

Cannabinoid Receptor (1)

AChR (1)

HMG-CoA Reductase (1)

Microtubule Associated (1)

Tyrosinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

NOD-like Receptor (NLR) (1)

p53 (1)

Kinesin (1)

HER (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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