已知活性化合物库

Bioactive Compounds Library Max

产品编号： L4010

已知活性库是 22706 个具有生物活性，能引起细胞、组织甚至个体生物学反应的化合物的集合。包括了正在进行临床前研究的药物分子，临床期的药物分子和已经上市的药物。靶点明确，信息全面，非常适合完成药物功能重定位、小分子诱导细胞分化以及机制研究中蛋白靶点确认等科研工作。

由于活性明确，靶点已知，很多科学家会从已知活性库中选择可以用于细胞诱导分化的小分子；通过单一或几个小分子的联合作用，筛选出能将各种体细胞诱导成为诱导多能干细胞，神经前体细胞，心肌细胞等的分子；甚至还有使用小分子组合在体内完成诱导分化的成功尝试。

已知活性库是对经典已知活性库的补充，添加了 TargetMol 特有，新颖的化合物（Part C），所有化合物靶点明确，且都进行过细胞水平活性测试，比上市药物库结构更为新颖，比类药化合物库更易发现活性化合物。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

22706个已知活性化合物的集合，可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认；
所有化合物都有相应的靶点信息的描述，活性研究更有保障和依据；
是老药新用、细胞诱导靶点筛选的有效工具；
涵盖多个疾病研究领域，如癌症、代谢、免疫和心血管系统等；
详细的说明书，化合物结构、靶点信息、活性描述等；
结构多样，药效显著，可渗透细胞；

化合物库定制

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化合物库组成

Apoptosis (1141)

Antibacterial (885)

Autophagy (819)

Endogenous Metabolite (801)

Antibiotic (535)

5-HT Receptor (361)

AChR (305)

Antifungal (287)

Parasite (283)

COX (271)

Adrenergic Receptor (250)

DNA/RNA Synthesis (244)

NF-κB (240)

Dopamine Receptor (224)

CDK (217)

HIV Protease (211)

Calcium Channel (200)

PI3K (200)

Potassium Channel (197)

EGFR (182)

Reactive Oxygen Species (174)

P450 (173)

Histamine Receptor (168)

PDE (165)

VEGFR (162)

Epigenetic Reader Domain (158)

Dehydrogenase (155)

Sodium Channel (147)

Influenza Virus (143)

GABA Receptor (139)

Antioxidant (137)

PPAR (132)

GluR (129)

Histone Methyltransferase (124)

Microtubule Associated (124)

HDAC (123)

TRP/TRPV Channel (121)

JAK (111)

TNF (110)

mTOR (106)

Wnt/beta-catenin (106)

GPR (103)

Topoisomerase (103)

Akt (102)

p38 MAPK (101)

FLT (100)

ERK (99)

Ferroptosis (98)

Prostaglandin Receptor (98)

Estrogen/progestogen Receptor (97)

Src (97)

Phosphatase (96)

PDGFR (94)

AChE (92)

Adenosine Receptor (92)

iGluR (92)

SARS-CoV (89)

STAT (89)

Estrogen Receptor/ERR (86)

HCV Protease (85)

PKC (85)

PARP (84)

FGFR (82)

AMPK (81)

GSK-3 (81)

NMDAR (81)

IL Receptor (79)

Opioid Receptor (79)

RAAS (79)

Nucleoside Antimetabolite/Analog (78)

Caspase (77)

Raf (77)

Virus Protease (76)

NO Synthase (75)

BCL (73)

c-Kit (73)

MMP (73)

c-Met/HGFR (69)

Ras (69)

MAO (68)

Androgen Receptor (67)

Antiviral (67)

Glucocorticoid Receptor (67)

Lipoxygenase (67)

Proteasome (67)

HSP (66)

Phospholipase (66)

TLR (66)

ATPase (64)

Bcr-Abl (64)

HBV (64)

Sirtuin (64)

Beta Amyloid (62)

HSV (62)

Mitochondrial Metabolism (62)

Anti-infection (61)

Cannabinoid Receptor (61)

ROS (59)

TGF-beta/Smad (58)

ALK (56)

Aurora Kinase (56)

Mitophagy (54)

Tyrosinase (54)

Drug Metabolite (53)

MAPK (53)

BTK (51)

E1/E2/E3 Enzyme (51)

HIF/HIF Prolyl-Hydroxylase (51)

JNK (51)

DUB (50)

HER (48)

MEK (48)

Antifection (47)

Casein Kinase (47)

Nrf2 (47)

Tyrosine Kinases (47)

Carbonic Anhydrase (46)

CCR (46)

Monoamine Oxidase (46)

NOS (46)

ROCK (46)

Interleukin (45)

Transferase (45)

PKA (44)

IκB/IKK (43)

p53 (43)

P-gp (43)

Reverse Transcriptase (43)

HIF (42)

Histone Demethylase (42)

Retinoid Receptor (42)

Gamma-secretase (41)

IGF-1R (41)

Serine/threonin kinase (41)

DNA-PK (39)

Integrin (39)

P2X Receptor (39)

Serotonin Transporter (39)

S1P Receptor (38)

CXCR (37)

c-RET (36)

Cysteine Protease (35)

Norepinephrine (35)

TAM Receptor (35)

Immunology/Inflammation related (34)

LPL Receptor (34)

CaMK (33)

Hedgehog/Smoothened (33)

Reductase (33)

ribosome (33)

Serine Protease (33)

Histone Acetyltransferase (32)

Proton pump (32)

S6 Kinase (32)

Trk receptor (32)

FAK (31)

Chloride channel (30)

FAAH (30)

Glucosidase (30)

RIP kinase (30)

Sigma receptor (30)

Ligand for E3 Ligase (29)

PLK (29)

Progesterone Receptor (29)

c-Fms (28)

Fatty Acid Synthase (27)

NADPH (27)

transporter (27)

Aryl Hydrocarbon Receptor (26)

CFTR (26)

Glucokinase (26)

Mdm2 (26)

NOD (26)

Thrombin (26)

ATM/ATR (25)

DPP-4 (25)

Syk (25)

Acyltransferase (24)

Chk (24)

Kinesin (24)

Protease-activated Receptor (24)

Amino Acids and Derivatives (23)

DNA Alkylator/Crosslinker (23)

DNA Methyltransferase (23)

PERK (23)

Pim (23)

Rho (23)

DNA (22)

Endothelin Receptor (22)

FXR (22)

HMG-CoA Reductase (22)

Indoleamine 2,3-Dioxygenase (IDO) (22)

PDK (22)

ROR (22)

Smo (22)

AhR (21)

Glutathione Peroxidase (21)

Lipase (21)

Neurokinin receptor (21)

P2Y Receptor (21)

SGLT (21)

Thyroid hormone receptor(THR) (21)

Epoxide Hydrolase (20)

Glucagon Receptor (20)

IRAK (20)

MRP (20)

DYRK (19)

Factor Xa (19)

Guanylate cyclase (19)

Hydroxylase (19)

LRRK2 (19)

LTR (19)

Xanthine Oxidase (19)

cAMP (18)

Complement System (18)

PAK (18)

STING (18)

Antifolate (17)

DHFR (17)

LPA Receptor (17)

OX Receptor (17)

PD-1/PD-L1 (17)

IRE1 (16)

Leukotriene Receptor (16)

Myosin (16)

Neuropeptide Y Receptor (16)

NOD-like Receptor (NLR) (16)

Aromatase (15)

BACE (15)

c-Myc (15)

DNA Alkylation (15)

DNA gyrase (15)

Liver X Receptor (15)

Platelet aggregation (15)

YAP (15)

CSF-1R (14)

Ephrin Receptor (14)

GTPase (14)

IAP (14)

Lipid (14)

PGE Synthase (14)

PI4K (14)

ABC (13)

Aminopeptidase (13)

cholecystokinin (13)

ROS Kinase (13)

RSV (13)

Vasopressin Receptor (13)

Beta-Secretase (12)

CETP (12)

GPCR19 (12)

Telomerase (12)

Acetyl-CoA Carboxylase (11)

Bradykinin Receptor (11)

CaSR (11)

Discoidin Domain Receptor (DDR) (11)

Free radical scavengers (11)

GHSR (11)

Isocitrate Dehydrogenase (IDH) (11)

Melanocortin Receptor (11)

Monoamine Transporter (11)

Monocarboxylate transporter (11)

NADPH-oxidase (11)

Neurotensin Receptor (11)

PAI-1 (11)

Phosphorylase (11)

Stearoyl-CoA Desaturase (SCD) (11)

IDO (10)

IFNAR (10)

Imidazoline Receptor (10)

LDL (10)

Melatonin Receptor (10)

NAMPT (10)

PKM (10)

ATP Citrate Lyase (9)

BCRP (9)

CAT (9)

GRK (9)

MLK (9)

MT Receptor (9)

PROTACs (9)

SGK (9)

UGT (9)

Adenylyl cyclase (8)

Arrestin (8)

ASK (8)

Dynamin (8)

Glutaminase (8)

GST (8)

Ligands for Target Protein for PROTAC (8)

Neprilysin (8)

Porcupine (8)

PTEN (8)

Wee1 (8)

Annexin A (7)

Arginase (7)

GlyT (7)

MNK (7)

Na+/Ca2+ Exchanger (7)

OCT (7)

p97 (7)

PAD (7)

SIK (7)

Tie-2 (7)

AAK1 (AP2 associated kinase 1) (6)

Adenosine deaminase (6)

APC (6)

Aquaporin (6)

Carboxypeptidase (6)

CRISPR/Cas9 (6)

FLAP (6)

GPX (6)

MAGL (6)

MELK (6)

Molecular Glues (6)

MyD88 (6)

OAT (6)

PAFR (6)

RAR/RXR (6)

Somatostatin (6)

TOPK (6)

ACK (5)

Amylase (5)

Angiotensin-converting Enzyme (ACE) (5)

BMI-1 (5)

Bombesin Receptor (5)

cell cycle arrest (5)

cGAS (5)

CGRP Receptor (5)

CRFR (5)

CRM1 (5)

Decarboxylase (5)

DprE1 (5)

Gap Junction Protein (5)

GNRH Receptor (5)

Hippo pathway (5)

LIM Kinase (5)

Methionine Adenosyltransferase (MAT) (5)

MTH1 (5)

OXPHOS (5)

Oxytocin Receptor (5)

PYK2 (5)

TSH Receptor (5)

VDAC (5)

Adiponectin receptor (4)

advanced glycation end products (4)

CD73 (4)

Cell wall (4)

DAPK (4)

Galectin (4)

KSP (4)

MALT (4)

Melanin-concentrating Hormone Receptor (MCHR) (4)

NEDD8 (4)

NPC1L1 (4)

PROTAC Linker (4)

Pyroptosis (4)

Survivin (4)

Thrombopoietin Receptor (4)

AIM2 (3)

Apelin receptor (3)

CD38 (3)

CPT (3)

GluCls (3)

Glutathione reductase (3)

Haspin Kinase (3)

Hck (3)

HCN Channel (3)

Hexokinase (3)

KLF (3)

Na-K-Cl cotransporter (3)

Necroptosis (3)

RANKL/RANK (3)

Transaminase (3)

ATTECs (2)

EBI2/GPR183 (2)

Fas/FasL (2)

gp120/CD4 (2)

GSNOR (2)

hCE (2)

Integrase (2)

lysosomal autophagy (2)

NUDIX hydrolase (2)

PGC-1α (2)

Prolyl Endopeptidase (PREP) (2)

Protease (2)

Taste receptor (2)

VDA (2)

aconitase (1)

Anion Exchanger (1)

CYP19A1 (1)

FABP (1)

Fer/FerT kinase (1)

FKBP (1)

FOXO1 (1)

HuR (1)

Hydrogenase (1)

LHRH (1)

Motilin Receptor (1)

N-Acetylglucosaminyltransferase (1)

Neuropeptide W (1)

NMU2R (1)

PACAP (1)

Piezo Channel (1)

Procollagen C Proteinase (1)

RXFP receptor (1)

Stemness kinase (1)

stilbene oxidase (1)

Thioredoxin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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