SCF Protein, Mouse, Recombinant

Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

规格	价格/CNY		数量
10 μg	￥ 870	现货
50 μg	￥ 1,960	5日内发货
500 μg	￥ 8,880	5日内发货
1 mg	￥ 13,900	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 870

现货

50 μg

￥ 1,960

5日内发货

500 μg

￥ 8,880

5日内发货

1 mg

￥ 13,900

5日内发货

生物活性

Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 4-12 ng/ml. (QC verified)

TargetMol Bioactive

产品描述

种属	Mouse
表达系统	E. coli
标签	None
蛋白编号	P20826
别名	SCF, Hematopoietic growth factor KL, MGF, Steel factor, Mast cell growth factor, Stem cell factor, Kit ligand
氨基酸序列	Lys26-Ala189
蛋白构建	Recombinant Mouse Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Lys26-Ala189 is expressed.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	16 KDa, reducing conditions

内毒素	Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

计算器

复溶计算器

重组蛋白稀释计算器

比活力计算器

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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SCF Protein, Mouse, Recombinant

计算器

技术支持

Keywords