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STAT

STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN1631 Eupalinolide K
野马追内酯 K
108657-10-9
Eupalinolide K 是来自野马追的一种倍半萜内酯,是 STAT3抑制剂,可作为迈克尔反应受体。
TN1840 Kurarinol
苦参醇
855746-98-4 98%
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
T78983 STAT3 degrader-2
化合物 STAT3 degrader-2
2497583-03-4 98%
STAT3degrader-2为基于PROTAC技术的STAT3降解剂,能有效下调总STAT3蛋白水平, 适用于癌症等病理条件的研究。
T79185 STAT6-IN-2
化合物 STAT6-IN-2
1355594-85-2 98%
STAT6-IN-2 (Comp R-84) 是STAT6的一种抑制剂,能够抑制嗜酸粒细胞趋化因子-3的分泌,常用于免疫疾病研究。
T79186 STAT6-IN-3
化合物 STAT6-IN-3
371919-80-1 98%
STAT6-IN-3 (Compound 18a),一种针对STAT6的Src同源2 (SH2) 结构域的抑制剂,具有44 nM的IC50值。该化合物主要适用于研究哮喘等炎症性疾病。
T79662 STAT3-IN-20
化合物 STAT3-IN-20
2768427-54-7 98%
STAT3-IN-20(Compound 40)是一种选择性地靶向STAT3的SH2结构域,展现了在DU145和MDA-MB-231癌细胞中的抗增殖效果(IC50分别为2.97 μM和3.26 μM),并诱导细胞周期停滞与细胞凋亡。该抑制剂有效抑制了STAT3的磷酸化、核内易位及其下游基因的转录活性(IC50: 0.65...
T80639 HJC0152 free base
化合物 HJC0152 free base
1420290-88-5 98%
HJC0152 (free base) 是一种口服活性的有效STAT3抑制剂,能够抑制细胞周期进程并诱导细胞凋亡(apoptosis)。此外,HJC0152 (free base) 在小鼠体内显著抑制MDA-MB-231 异种移植瘤的生长。
T80847 W1131 TFA
化合物 W1131 TFA
98%
W1131 TFA 是一种抑制STAT3并诱导铁死亡(ferroptosis)的有效化合物。在胃癌的皮下异种移植模型、类器官模型以及PDX模型中,它都能显著阻止疾病的发展。此外,W1131能有效缓解癌细胞对5-FU的化学耐药性。该化合物还通过调节IL6-JAK-STAT3和铁死亡(ferroptosis)通路来影响细胞周...
T81690 Neocucurbitacin A
化合物 Neocucurbitacin A
352359-53-6 98%
Neocucurbitacin A (compound 7)是一种从沉香果皮提取的STAT3抑制剂,常用于抗癌研究。
T14925 Cenisertib
化合物 T14925
871357-89-0 98%
Cenisertib 是一种有效的 ATP 竞争性的多激酶抑制剂,对 Aurora-kinase-A/B,ABL1,AKT,STAT5, FLT3 的活性具有抑制作用,对FER 及其同源物的激酶也显示出抑制作用。Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长,也抑制异种移植模型中...
TN4035 Eupalinolide I
化合物 TN4035
1402067-84-8 98%
Eupalinolide I is a natural product from Eupatorium lindleyanum.
TN3587 Capillarisin
化合物 TN3587
56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T13010 STAT3-IN-3
化合物 T13010
2361304-26-7 98%
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
TN3410 Anatabine
化合物 TN3410
581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3525 Boehmenan
化合物 TN3525
57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN2511 Britannilactone diacetate
化合物 TN2511
1286694-67-4 98%
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T11449L2 Golotimod (TFA) (229305-39-9 free base)
化合物 T11449L2
T11449L2 98%
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
TN4774 Physalin A
化合物 TN4774
23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T12905 SI-109
化合物 T12905
T12905 98%
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T19886 Cirsilineol
甲基条叶蓟素
41365-32-6 98%
Cirsilineol (Eupatrin) 是从 Artemisia vestita Wall 的草本植物中分离出来的,具有免疫抑制、抗增殖和抗肿瘤特性。 Cirsilineol 通过线粒体途径选择性诱导细胞凋亡。
Eupalinolide K
TN1631
Eupalinolide K 是来自野马追的一种倍半萜内酯,是 STAT3抑制剂,可作为迈克尔反应受体。
Kurarinol
TN1840
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
STAT3 degrader-2
T78983
STAT3degrader-2为基于PROTAC技术的STAT3降解剂,能有效下调总STAT3蛋白水平, 适用于癌症等病理条件的研究。
STAT6-IN-2
T79185
STAT6-IN-2 (Comp R-84) 是STAT6的一种抑制剂,能够抑制嗜酸粒细胞趋化因子-3的分泌,常用于免疫疾病研究。
STAT6-IN-3
T79186
STAT6-IN-3 (Compound 18a),一种针对STAT6的Src同源2 (SH2) 结构域的抑制剂,具有44 nM的IC50值。该化合物主要适用于研究哮喘等炎症性疾病。
STAT3-IN-20
T79662
STAT3-IN-20(Compound 40)是一种选择性地靶向STAT3的SH2结构域,展现了在DU145和MDA-MB-231癌细胞中的抗增殖效果(IC50分别为2.97 μM和3.26 μM),并诱导细胞周期停滞与细胞凋亡。该抑制剂有效抑制了STAT3的磷酸化、核内易位及其下游基因的转录活性(IC50: 0.65...
HJC0152 free base
T80639
HJC0152 (free base) 是一种口服活性的有效STAT3抑制剂,能够抑制细胞周期进程并诱导细胞凋亡(apoptosis)。此外,HJC0152 (free base) 在小鼠体内显著抑制MDA-MB-231 异种移植瘤的生长。
W1131 TFA
T80847
W1131 TFA 是一种抑制STAT3并诱导铁死亡(ferroptosis)的有效化合物。在胃癌的皮下异种移植模型、类器官模型以及PDX模型中,它都能显著阻止疾病的发展。此外,W1131能有效缓解癌细胞对5-FU的化学耐药性。该化合物还通过调节IL6-JAK-STAT3和铁死亡(ferroptosis)通路来影响细胞周...
Neocucurbitacin A
T81690
Neocucurbitacin A (compound 7)是一种从沉香果皮提取的STAT3抑制剂,常用于抗癌研究。
Cenisertib
T14925
Cenisertib 是一种有效的 ATP 竞争性的多激酶抑制剂,对 Aurora-kinase-A/B,ABL1,AKT,STAT5, FLT3 的活性具有抑制作用,对FER 及其同源物的激酶也显示出抑制作用。Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长,也抑制异种移植模型中...
Eupalinolide I
TN4035
Eupalinolide I is a natural product from Eupatorium lindleyanum.
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
STAT3-IN-3
T13010
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Golotimod (TFA) (229305-39-9 free base)
T11449L2
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
SI-109
T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
Cirsilineol
T19886
Cirsilineol (Eupatrin) 是从 Artemisia vestita Wall 的草本植物中分离出来的,具有免疫抑制、抗增殖和抗肿瘤特性。 Cirsilineol 通过线粒体途径选择性诱导细胞凋亡。
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