STAT

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis which enhances the survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
Inhibitors Catalog Download
产品编号 产品名称
T6308 StatticHOT Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM).
T2505 NSC 74859HOT S3I-201 is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
T1038 FludarabineHOT Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T5668 Triacetylresveratrol Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in panc...
T5S0168 Atractylenolide II 1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
T3S1775 Tectochrysin 1. Tectochrysin has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apopt...
T6S1373 Casticin 1. Vitexicarpin can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. 2. Vitexicarpin may becom...
T4S0145 Corylifol A 1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. ...
T4476 AS1517499 AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
T5S1607 Morusin 1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopt...
T4S2126 Ginkgetin 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
T6S0141 Corylin Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
T4650 C188-9 C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
T9949 NSC 370284 NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level o...
TQ0052 SH5-07 SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
T4216 STAT5-IN-1 STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
TQ0196 Cucurbitacin I Cucurbitacin I, a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
TN2346 Mogrol Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
T8213 Isolinderalactone Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
TP1433 CMD178 TFA CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.
TP1856 Colivelin Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
TN1013 Cucurbitacin D Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
TN1059 Ganoderic acid B Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B acts as a telomerase inhibitor to inhibit the activ...
TN1237 3-O-Methylgallic acid 3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
TN1405 Arnicolide D Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T4615 Balsalazide sodium hydrate Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing pr...
T4234 HJC0152 hydrochloride HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
T4034 Solamargine Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
T0711 Niclosamide Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
T6537 HO-3867 HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
T3398 Icaritin Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopto...
T3708 BP-1-102 BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
T6669 SH-4-54 SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T3380 Homoharringtonine Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myel...
T2789 Scutellarin Scutellarin, an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regul...
T2814 Cryptotanshinone Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727...
T3971 CASIN CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T2867 Diosgenin Diosgenin is a spirostan found in DIOSCOREA and other plants. It has favorable effects in the improvement of diabetes and regulation of lipid metabolism.
TN1673 Garcinone C Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
T2896 Alantolactone Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
T2896 Alantolactone Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-reg...
T6677 Sophocarpine Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast forma...
T2168 2-NP 2-NP is a STAT1 enhancer.
T3218 Napabucasin Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.
T2156 WP1066 WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 ha...
T0433 Artesunate Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
T1563 Nifuroxazide Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT...
TN1620 Eriocalyxin B Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
TN1674 Garcinone D Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
T9945 MNK8 3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
TN3541 Broussonin E Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TMA1743 Ergosterol peroxide Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN4035 Eupalinolide I Eupalinolide I is a natural product from Eupatorium lindleyanum.
TN4356 Jolkinolide A Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN4379 Kansuinine A Kansuinine A, a 95% ethanol extract from the roots of E. kansui, possesses an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2.
TN4490 Manassantin B Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
TN2511 Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN4604 Myricanone Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T8719 SC99 SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregatio...
T21267 HODHBt HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
T9043 AS1810722 AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bic...
T28865 STAT3-IN-B9 STAT3-IN-B9 is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
TN6739 Angoline Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene e...
T9339 Stafia-1 Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
T4605 NT157 NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal c...
T35544 ML115 ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
TN1775 Isocryptotanshinone Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative...
T13010 STAT3-IN-3 STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
TN1840 Kurarinol Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varyi...
TN2269 Tetramethylcurcumin Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also ...
T8378 AS2863619 AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
T13009 STAT3-IN-1 STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor ...
T14330 Ascochlorin Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlor...
T8476 RSVA405 RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T14925 Cenisertib Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in ...
T15234 ENMD-1198 ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T11449L Golotimod Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and spl...
T12905 SI-109 SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T11449 Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
T5S0993 Kurarinone Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T11449L2 Golotimod (TFA) (229305-39-9 free base) Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
T13950 UC-514321 UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
T15582 InS3-54A18 inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
T8478 SC-43 SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
T8546 BD750 BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM i...
T22424 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation...
T8597 ML116 ML116 is a potent and selective STAT3 inhibitor.
T2S1040 Jolkinolide B Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T2S1975 Ponicidin Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicid...
T4672 Brevilin A Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor a...
T6995 Ochromycinone STA-21 is a selective STAT3 inhibitor.
Stattic HOT
T6308CAS 19983-44-9
Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 μM).
NSC 74859 HOT
T2505CAS 501919-59-1
S3I-201 is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
Fludarabine HOT
T1038CAS 21679-14-1
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Triacetylresveratrol
T5668CAS 42206-94-0
Acetyl-trans-resveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in panc...
Atractylenolide II
T5S0168CAS 73069-14-4
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
Tectochrysin
T3S1775CAS 520-28-5
1. Tectochrysin has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apopt...
Casticin
T6S1373CAS 479-91-4
1. Vitexicarpin can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. 2. Vitexicarpin may becom...
Corylifol A
T4S0145CAS 775351-88-7
1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. ...
AS1517499
T4476CAS 919486-40-1
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
Morusin
T5S1607CAS 62596-29-6
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopt...
Ginkgetin
T4S2126CAS 481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
Corylin
T6S0141CAS 53947-92-5
Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
C188-9
T4650CAS 432001-19-9
C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
NSC 370284
T9949CAS 116409-29-1
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level o...
SH5-07
TQ0052CAS 1456632-41-9
SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
STAT5-IN-1
T4216CAS 285986-31-4
STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
Cucurbitacin I
TQ0196CAS 2222-07-3
Cucurbitacin I, a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Mogrol
TN2346CAS 88930-15-8
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Isolinderalactone
T8213CAS 957-66-4
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
CMD178 TFA
TP1433CAS TP1433
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.
Colivelin
TP1856CAS 867021-83-8
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
Cucurbitacin D
TN1013CAS 3877-86-9
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
Ganoderic acid B
TN1059CAS 81907-61-1
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B acts as a telomerase inhibitor to inhibit the activ...
3-O-Methylgallic acid
TN1237CAS 3934-84-7
3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
Arnicolide D
TN1405CAS 34532-68-8
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
Balsalazide sodium hydrate
T4615CAS 150399-21-6
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing pr...
HJC0152 hydrochloride
T4234CAS 1420290-99-8
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
Solamargine
T4034CAS 20311-51-7
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
Niclosamide
T0711CAS 50-65-7
Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
HO-3867
T6537CAS 1172133-28-6
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
Icaritin
T3398CAS 118525-40-9
Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apopto...
BP-1-102
T3708CAS 1334493-07-0
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
SH-4-54
T6669CAS 1456632-40-8
SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
Saikosaponin D
T3913CAS 20874-52-6
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
Homoharringtonine
T3380CAS 26833-87-4
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myel...
Scutellarin
T2789CAS 27740-01-8
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regul...
Cryptotanshinone
T2814CAS 35825-57-1
Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727...
CASIN
T3971CAS 425399-05-9
CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
Diosgenin
T2867CAS 512-04-9
Diosgenin is a spirostan found in DIOSCOREA and other plants. It has favorable effects in the improvement of diabetes and regulation of lipid metabolism.
Garcinone C
TN1673CAS 76996-27-5
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
Alantolactone
T2896CAS 546-43-0
Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
Alantolactone
T2896CAS 546-43-0
Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
Cucurbitacin B
T3404CAS 6199-67-3
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-reg...
Sophocarpine
T6677CAS 6483-15-4
Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast forma...
2-NP
T2168CAS 65182-56-1
2-NP is a STAT1 enhancer.
Napabucasin
T3218CAS 83280-65-3
Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.
WP1066
T2156CAS 857064-38-1
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 ha...
Artesunate
T0433CAS 88495-63-0
Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
Nifuroxazide
T1563CAS 965-52-6
Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT...
Eriocalyxin B
TN1620CAS 84745-95-9
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
Garcinone D
TN1674CAS 107390-08-9
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
MNK8
T9945CAS 2055078-49-2
3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Agrimonolide
TN3364CAS 21499-24-1
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Boehmenan
TN3525CAS 57296-22-7
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
Broussonin E
TN3541CAS 90902-21-9
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Ergosterol peroxide
TMA1743CAS 2061-64-5
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Eupalinolide I
TN4035CAS 1402067-84-8
Eupalinolide I is a natural product from Eupatorium lindleyanum.
Jolkinolide A
TN4356CAS 37905-07-0
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
Kansuinine A
TN4379CAS 57701-86-7
Kansuinine A, a 95% ethanol extract from the roots of E. kansui, possesses an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2.
Manassantin B
TN4490CAS 88497-88-5
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
Britannilactone diacetate
TN2511CAS 1286694-67-4
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Myricanone
TN4604CAS 32492-74-3
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
SC99
T8719CAS 882290-02-0
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregatio...
HODHBt
T21267CAS 28230-32-2
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
AS1810722
T9043CAS 909561-15-5
AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bic...
STAT3-IN-B9
T28865CAS 825611-06-1
STAT3-IN-B9 is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
Angoline
TN6739CAS 21080-31-9
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene e...
Stafia-1
T9339CAS 2582757-90-0
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
NT157
T4605CAS 1384426-12-3
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal c...
ML115
T35544CAS 912798-42-6
ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Isocryptotanshinone
TN1775CAS 22550-15-8
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative...
STAT3-IN-3
T13010CAS 2361304-26-7
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Kurarinol
TN1840CAS 855746-98-4
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varyi...
Tetramethylcurcumin
TN2269CAS 52328-97-9
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also ...
AS2863619
T8378CAS 2241300-51-4
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
STAT3-IN-1
T13009CAS 2059952-75-7
STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor ...
Ascochlorin
T14330CAS 26166-39-2
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlor...
RSVA405
T8476CAS 140405-36-3
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
Cenisertib
T14925CAS 871357-89-0
Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in ...
ENMD-1198
T15234CAS 864668-87-1
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
Golotimod
T11449LCAS 229305-39-9
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and spl...
SI-109
T12905CAS T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
Golotimod hydrochloride (229305-39-9 free base)
T11449CAS T11449
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
Kurarinone
T5S0993CAS 34981-26-5
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
Golotimod (TFA) (229305-39-9 free base)
T11449L2CAS T11449L2
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
UC-514321
T13950CAS 299420-83-0
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
inS3-54A18
T15582CAS 328998-53-4
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
SC-43
T8478CAS 1400989-25-4
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
BD750
T8546CAS 892686-59-8
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM i...
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
T22424CAS 1313019-65-6
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation...
ML116
T8597CAS 744270-00-6
ML116 is a potent and selective STAT3 inhibitor.
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicid...
Brevilin A
T4672CAS 16503-32-5
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor a...
Ochromycinone
T6995CAS 111540-00-2
STA-21 is a selective STAT3 inhibitor.
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