Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAR407899 是一种选择性的 ATP 竞争性ROCK 抑制剂,对ROCK-2的IC50值为 135 nM,对人和大鼠ROCK-2的Ki 值分别为 36 和 41 nM。它是 Rho 激酶抑制剂,有效抑制 endothelin-1 诱导的肾阻力动脉收缩。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
2 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 496 | 现货 | ||
10 mg | ¥ 745 | 现货 | ||
25 mg | ¥ 1,380 | 现货 | ||
50 mg | ¥ 2,230 | 现货 | ||
100 mg | ¥ 3,560 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 546 | 现货 |
产品描述 | SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
靶点活性 | ROCK2:102 nM (IC50), ROCK1:276 nM (IC50) |
体内活性 | In vivo, SAR407899 dose-dependently induced rabbit penile erection, with greater potency and longer duration of action than sildenafil[1]. |
动物实验 | Compared the effects of SAR407899, the Rho-kinase inhibitor Y-27632 and the PDE5 inhibitor sildenafil for their ability to relax corpus cavernosum strips contracted with phenylephrine in healthy and diabetic animals. Strips were obtained from WKY, spontaneous hypertensive (SHR), control CD, and diabetic CD rats, humans, control and diabetic rabbits. Diabetes was induced by streptozotocin or alloxan injection. In vivo penile erection (length) induced by drugs was measured in conscious rabbits[1]. |
分子量 | 244.29 |
分子式 | C14H16N2O2 |
CAS No. | 923359-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (24.56 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.0935 mL | 20.4675 mL | 40.935 mL | 102.3374 mL |
5 mM | 0.8187 mL | 4.0935 mL | 8.187 mL | 20.4675 mL | |
10 mM | 0.4093 mL | 2.0467 mL | 4.0935 mL | 10.2337 mL | |
20 mM | 0.2047 mL | 1.0234 mL | 2.0467 mL | 5.1169 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SAR407899 923359-38-0 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK Rho Rho-associated kinase ROK SAR-407899 Rho-kinase Rho-associated protein kinase SAR 407899 inhibit Inhibitor inhibitor