| T1725 |
Y-27632 dihydrochloride |
Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM). |
| T1898 |
RKI-1447 |
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
| T1920 |
Capivasertib |
Capivasertib (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3). |
| T2011 |
RKI-1313 |
RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion. |
| T2155 |
Thiazovivin |
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC. |
| T2398 |
Tofacitinib Citrate |
Tofacitinib citrate is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM). |
| T2482 |
AT13148 |
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
| T2633 |
GSK429286A |
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). |
| T3060 |
Fasudil hydrochloride |
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. |
| T3513 |
GSK180736A |
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effecti |
| T3518 |
GSK269962A |
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
| T4095 |
ZINC00881524 |
ZINC00881524 is an effective and specific ROCK inhibitor. |
| T6057 |
URMC-099 |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). |
| T6321 |
Tofacitinib |
Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis. |
| T6867 |
KD025 |
KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
| T4276 |
Hydroxyfasudil Hydrochloride |
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
| T7301 |
BDP5290 |
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) |
| T7492 |
Ripasudil free base |
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent. |
| T7552 |
H-1152 |
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM). |
