T2155 |
ThiazovivinHOT |
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
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T1725 |
Y-27632 dihydrochlorideHOT |
Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM).
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T19913 |
CKI-7 |
CKI-7 2HCl is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 2HCl also in...
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T3518 |
GSK269962A |
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
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T7492 |
Ripasudil free base |
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
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T4095 |
ZINC00881524 |
ZINC00881524 is an effective and specific ROCK inhibitor.
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T4276 |
Hydroxyfasudil Hydrochloride |
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
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T6867 |
Belumosudil |
KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
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T2633 |
GSK429286A |
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
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T6321 |
Tofacitinib |
Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
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T3513 |
GSK180736A |
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM),...
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T7552 |
H-1152 |
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
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T1870 |
Y-27632 |
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
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T1898 |
RKI-1447 |
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
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T2011 |
RKI1313 |
RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
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T2482 |
AT13148 |
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
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T3060 |
Fasudil hydrochloride |
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
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T7301 |
BDP5290 |
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
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TQ0110 |
ROCK-IN-2 |
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
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T4276L |
Hydroxyfasudil |
Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
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T13972 |
Y-9738 |
Y-9738 is an agent of hypolipidemic.
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T23308 |
SAR407899 hydrochloride |
SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and ra...
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T16855 |
SB-772077B dihydrochloride |
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
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T10358 |
Netarsudil Dihydrochloride |
Netarsudil Dihydrochloride is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (I...
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T15808 |
Merestinib dihydrochloride |
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
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T15798 |
LX7101 |
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
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T13424 |
(1R,2S)-VU0155041 |
(1R,2S)-VU0155041 is a partial agonist of mGluR4(EC50 of 2.35 μM).
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T13364 |
YAP/TAZ inhibitor-1 |
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
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T14989 |
CMPD101 |
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
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TQ0183 |
Narciclasine |
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
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T14960 |
Chroman 1 |
Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).
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T12747 |
ROCK2-IN-2 |
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
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T12746 |
ROCK inhibitor-2 |
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
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T12721 |
Rho-Kinase-IN-1 |
Rho-Kinase-IN-1 is a inhibitor of Rho kinase (ROCK) with Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively
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TN1533 |
Cucurbitacin A |
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
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TQ0319 |
Ripasudil |
Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
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TQ0187 |
SR-3677 |
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
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T1606 |
Fasudil |
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
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