T1237 |
Azathioprine |
Azathioprine, an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation. |
T2014 |
CCG1423 |
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. |
T2427 |
EHop016 |
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3. |
T3553 |
Y16 |
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions. |
T6342 |
NSC 23766 trihydrochloride |
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42. |
T6483 |
EHT 1864 |
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM). |
T6739 |
Zoledronic Acid |
Zoledronate is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hy |
T7391 |
SAR407899 |
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
T7764 |
CCG-222740 |
CCG-222740 is an inhibitor of Rho/MRTF pathway |
T12452 |
Digeranyl bisphosphonate |
Digeranyl bisphosphonate is a potent inhibitor of geranylgeranylpyrophosphate (GGPP) synthase. |
T14004 |
1A-116 |
1A-116 is a specific inhibitor of Rac1 . |
T16745 |
Rhosin hydrochloride |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydr |
T16746 |
Rhosin |
Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact |