Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,250 | 5日内发货 | ||
5 mg | ¥ 2,120 | 5日内发货 | ||
25 mg | ¥ 5,790 | 6-8周 | ||
50 mg | ¥ 7,520 | 6-8周 | ||
100 mg | ¥ 11,600 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,330 | 5日内发货 |
产品描述 | RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM). |
靶点活性 | HCV:171 nM |
体外活性 | RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1]. |
体内活性 | Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of RO-9187 (1.4 and 26 μM ) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with RO-9187 (2000 mg/kg/day)[1]. |
分子量 | 284.23 |
分子式 | C9H12N6O5 |
CAS No. | 876708-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 7.14 mg/mL (25.12 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 3.5183 mL | 17.5914 mL | 35.1828 mL | 87.9569 mL |
5 mM | 0.7037 mL | 3.5183 mL | 7.0366 mL | 17.5914 mL | |
10 mM | 0.3518 mL | 1.7591 mL | 3.5183 mL | 8.7957 mL | |
20 mM | 0.1759 mL | 0.8796 mL | 1.7591 mL | 4.3978 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RO-9187 876708-03-1 Microbiology/Virology Proteases/Proteasome HCV Protease RO 9187 RO9187 Inhibitor inhibitor inhibit