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Fatostatin hydrobromide

产品编号: T6832 别名:

Fatostatin A HBr,Fatostatin A,Fatostatin HBr,Fatostatin

Fatostatin 是一种SREBP活化的特异性抑制剂,可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用,能抑制ob/ob小鼠的高血糖。它抑制了细胞中成脂基因的转录。
陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
 Chemical Structure CAS:298197-04-3
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin suppresses cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. Fatostatin blocks the activation of SREBPs in cells in tissue culture.Fatostatin also reduced in vitro invasion and migration in both cell lines. Further, fatostatin causes G2/M cell cycle arrest and induces apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP.
Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group. Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
Cell lines: CHO-K1 cells. Concentrations: 20 μM. Incubation Time: 20 h. Method: On day 0,CHO-K1 cells are plated out onto a 96-well plate in medium A.On day 2,the cells are transiently cotransfected with pCMV-PLAP-BP2(513–1141),pCMV-SCAP,and pAc-β-gal,using Lipofectamine reagent.After incubation for 5 hr,the cells are washed with PBS and then incubated in medium B,in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol).After 20 hr of incubation,an aliquot of the medium is assayed for secreted alkaline phosphatase activity.The cells in each well are lysed and used for measurement of β-galactosidase activities.The alkaline phosphatase activity is normalized by the activity of β-galactosidase.
Animal Models: Obese (ob/ob) mice (C57BL/6J background). Formulation: 10% DMSO in PBS. Dosages: 30 mg/kg. Administration: intraperitoneal injection
298197-04-3
C18H19BrN2S
375.33
Fatostatin A HBr;Fatostatin A;Fatostatin HBr;Fatostatin;Fatostatin hydrobromide
DMSO:7 mg/mL (18.65 mM)
Ethanol:58 mg/mL (154.53 mM)
H2O:<1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
剂量换算 Fatostatin hydrobromide 298197-04-3
对于各种应用,安全且有效的用药剂量是很有必要的了解更多
体内实验配液计算器
第一步:请输入动物实验的基本信息
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将已知质量的化合物溶解到所需浓度所需的溶液体积
已知质量的化合物在一定体积内形成的溶液的浓度
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制备已知体积和浓度溶液所需的化合物质量
将已知质量的化合物溶解到所需浓度所需的溶液体积
已知质量的化合物在一定体积内形成的溶液的浓度
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抑制剂处理说明 中可以找到您可能遇到的问题的答案。 主题包括如何准备储备溶液,如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

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