神经递质受体化合物库

Neurotransmitter Receptor Compound Library

产品编号： L2610

神经递质是人类行为的化学基础。研究证实行为病理大都由一个或数个神经递质缺失或增多失平衡引起。躯体疾病也可由于特殊的神经径路障碍引起，例如帕金森病（PD）。脑内神经递质分为生物原胺类、氨基酸类、肽类、乙酰胆碱类等。生物原胺类神经递质包括：多巴胺（DA）、去甲肾上腺素（NE）、肾上腺素（E）、5-羟色胺（5-HT）也称（血清素）。氨基酸类神经递质包括：γ-氨基丁酸（GABA）、甘氨酸、谷氨酸、组胺。肽类神经递质分为：内源性阿片肽、P 物质、神经加压素、胆囊收缩素（CCK）、生长抑素、血管加压素和缩宫素、神经肽 Y。其它神经递质还有：核苷酸类、花生酸碱、阿南德酰胺、sigma 受体（σ受体）。在突触后膜或效应器细胞膜上有能与神经递质相结合的特殊蛋白质，称神经递质受体或突触后受体。许多精神药物作用于神经递质受体。

TargetMol 收集了 1513 种神经递质受体相关的化合物，可用于神经系统药物的开发。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1513种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
靶点包括5-HT receptor、AChR、GABA receptor、dopamine receptor、Opiod receptor等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

5-HT Receptor (347)

AChR (277)

Dopamine Receptor (219)

Adrenergic Receptor (212)

Histamine Receptor (152)

GABA Receptor (141)

GluR (91)

Adenosine Receptor (72)

Opioid Receptor (72)

AChE (71)

iGluR (68)

NMDAR (63)

Autophagy (56)

Endogenous Metabolite (54)

Apoptosis (40)

Norepinephrine (31)

Serotonin Transporter (28)

Antibacterial (27)

Calcium Channel (24)

Potassium Channel (23)

Parasite (19)

Sodium Channel (18)

Neuropeptide Y Receptor (17)

Endothelin Receptor (17)

P450 (15)

PDE (14)

Influenza Virus (11)

NF-κB (9)

HIV Protease (7)

Antifungal (7)

CaMK (7)

cholecystokinin (7)

Antibiotic (7)

Reactive Oxygen Species (6)

COX (6)

HDAC (6)

Phospholipase (6)

HCV Protease (5)

Mitophagy (5)

TRP/TRPV Channel (5)

P-gp (5)

TNF (5)

Histone Methyltransferase (4)

Dehydrogenase (4)

Ferroptosis (4)

Virus Protease (4)

ERK (4)

MAO (4)

Monoamine Transporter (4)

DNA/RNA Synthesis (4)

Beta Amyloid (4)

Adenosine deaminase (4)

Sigma receptor (4)

NO Synthase (4)

Chloride channel (3)

Transferase (3)

PI3K (3)

BACE (3)

RAAS (3)

ABC (3)

VEGFR (3)

Caspase (3)

Glucocorticoid Receptor (3)

Drug Metabolite (3)

P2X Receptor (3)

HSV (3)

Beta-Secretase (3)

Prostaglandin Receptor (3)

GPR (3)

AMPK (3)

Cannabinoid Receptor (3)

Tyrosinase (3)

Monoamine Oxidase (3)

Adenylyl cyclase (2)

NOS (2)

Transaminase (2)

Antioxidant (2)

DYRK (2)

Phosphatase (2)

GSK-3 (2)

Melatonin Receptor (2)

MRP (2)

PKA (2)

HBV (2)

PPAR (2)

PARP (2)

PAFR (2)

Gamma-secretase (2)

ROS (2)

BCL (2)

IL Receptor (2)

Aurora Kinase (2)

cAMP (2)

Lipoxygenase (2)

mTOR (2)

SARS-CoV (2)

RSV (2)

MEK (2)

Anti-infection (2)

Imidazoline Receptor (2)

HER (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

CAT (1)

Carbonic Anhydrase (1)

Integrin (1)

Amino Acids and Derivatives (1)

p38 MAPK (1)

Estrogen/progestogen Receptor (1)

Na+/Ca2+ Exchanger (1)

Arrestin (1)

NADPH (1)

GTPase (1)

Progesterone Receptor (1)

OCT (1)

Antifolate (1)

FXR (1)

Leukotriene Receptor (1)

PKC (1)

Aryl Hydrocarbon Receptor (1)

IAP (1)

Immunology/Inflammation related (1)

Annexin A (1)

Adiponectin receptor (1)

Bcr-Abl (1)

LDL (1)

GRK (1)

Raf (1)

MT Receptor (1)

GlyT (1)

Glucosidase (1)

Mitochondrial Metabolism (1)

Antifection (1)

Fatty Acid Synthase (1)

Bombesin Receptor (1)

Stearoyl-CoA Desaturase (SCD) (1)

CCR (1)

MMP (1)

PAD (1)

ACK (1)

Epigenetic Reader Domain (1)

DNA (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Androgen Receptor (1)

Interleukin (1)

TGF-beta/Smad (1)

EGFR (1)

Akt (1)

MAPK (1)

Acyltransferase (1)

Trk receptor (1)

Aminopeptidase (1)

Nrf2 (1)

GluCls (1)

GST (1)

Reverse Transcriptase (1)

STAT (1)

CRISPR/Cas9 (1)

Hydroxylase (1)

FGFR (1)

Gap Junction Protein (1)

Platelet aggregation (1)

FLT (1)

Syk (1)

NOD (1)

DNA Methyltransferase (1)

HMG-CoA Reductase (1)

Microtubule Associated (1)

HIF/HIF Prolyl-Hydroxylase (1)

FAK (1)

p53 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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