MAPK 抑制剂库

MAPK Inhibitor Library

产品编号： L1400

MAPK 是信号从细胞表面传导到细胞核内部的重要传递者。丝裂原活化蛋白激酶（MAPK）是一组能被不同的细胞外刺激活化的蛋白激酶，如细胞因子、神经递质、激素、细胞应激及细胞黏附等。所有的真核细胞都能表达MAPK，MAPK 通路的基本组成是一种从酵母到人类都保守的三级激酶模式，包括MAPK 激酶激酶（MKKK）、MAPK 激酶（MKK）和MAPK，这三种激酶能依次激活，MAPK 链是真核生物信号传递网络中的重要途径之一，在基因表达调控和细胞质功能活动中发挥关键作用。共同调节着细胞的生长、分化、对环境的应激适应、炎症反应等多种重要的细胞生理和病理过程。

TargetMol MAPK 抑制剂库是有365 个MAPK 信号通路相关的小分子的集合，用于研究MAPK 信号通路及相关疾病药物筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

365种与MAPK信号通路相关的生物活性小分子化合物的特有集合，可用于高通量筛选和高内涵筛选；
靶点含ERK、JNK、MEK、p38、MAPK、Raf、RSK、MNK等；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些活性化合物已得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (79)

ERK (78)

p38 MAPK (76)

Autophagy (70)

Raf (59)

Ras (52)

MEK (41)

JNK (39)

NF-κB (32)

MAPK (31)

S6 Kinase (25)

CDK (22)

Akt (21)

Src (14)

VEGFR (14)

Rho (10)

Caspase (10)

Aurora Kinase (9)

Endogenous Metabolite (9)

PDGFR (8)

c-Kit (8)

Ferroptosis (7)

mTOR (7)

Casein Kinase (7)

PI3K (6)

GSK-3 (6)

PKA (6)

Parasite (6)

ROCK (6)

TGF-beta/Smad (6)

c-RET (6)

TNF (6)

MLK (6)

Antifungal (5)

PKC (5)

Bcr-Abl (5)

BCL (5)

COX (5)

Antibacterial (5)

MNK (5)

STAT (5)

AMPK (5)

FLT (5)

PERK (4)

TOPK (4)

PARP (4)

MMP (4)

DNA/RNA Synthesis (4)

Trk receptor (4)

ASK (4)

P450 (4)

SGK (4)

Serine Protease (3)

Reactive Oxygen Species (3)

JAK (3)

IGF-1R (3)

EGFR (3)

LRRK2 (3)

FGFR (3)

Transferase (2)

c-Met/HGFR (2)

GTPase (2)

Mitophagy (2)

Aryl Hydrocarbon Receptor (2)

ROS (2)

DNA Alkylation (2)

AChE (2)

P-gp (2)

Antiviral (2)

Influenza Virus (2)

Beta Amyloid (2)

c-Fms (2)

KLF (2)

Syk (2)

Sodium Channel (2)

FAK (2)

NO Synthase (2)

Proton pump (1)

HCV Protease (1)

Integrin (1)

Estrogen/progestogen Receptor (1)

Dehydrogenase (1)

Antioxidant (1)

Adenosine Receptor (1)

BACE (1)

Histamine Receptor (1)

Tie-2 (1)

Glutathione Peroxidase (1)

Virus Protease (1)

c-Myc (1)

HBV (1)

Tyrosine Kinases (1)

FXR (1)

Calcium Channel (1)

Adrenergic Receptor (1)

CSF-1R (1)

Topoisomerase (1)

RIP kinase (1)

Drug Metabolite (1)

Glucosidase (1)

Antifection (1)

IL Receptor (1)

Chk (1)

ACK (1)

cAMP (1)

Epigenetic Reader Domain (1)

DNA (1)

Interleukin (1)

Beta-Secretase (1)

PGE Synthase (1)

TLR (1)

Ephrin Receptor (1)

transporter (1)

Nrf2 (1)

PAI-1 (1)

ALK (1)

MELK (1)

IκB/IKK (1)

GPX (1)

Aromatase (1)

PDK (1)

5-HT Receptor (1)

Hydroxylase (1)

Potassium Channel (1)

AChR (1)

BMI-1 (1)

NADPH-oxidase (1)

IRAK (1)

Tyrosinase (1)

Antibiotic (1)

HIF/HIF Prolyl-Hydroxylase (1)

AhR (1)

PD-1/PD-L1 (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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